[6-{cyclohexyl[4-(trifluoromethyl)piperidin-1-yl]methyl}-4'-(trifluoromethyl)biphenyl-3-yl]acetic acid

Base Information

Chemical Name:[6-{cyclohexyl[4-(trifluoromethyl)piperidin-1-yl]methyl}-4'-(trifluoromethyl)biphenyl-3-yl]acetic acid
CAS No.:1257396-75-0
Molecular Formula:C₂₈H₃₁F₆NO₂
Molecular Weight:527.55
Hs Code.:

Synonyms:[6-{cyclohexyl[4-(trifluoromethyl)piperidin-1-yl]methyl}-4'-(trifluoromethyl)biphenyl-3-yl]acetic acid

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Chemical Property of [6-{cyclohexyl[4-(trifluoromethyl)piperidin-1-yl]methyl}-4'-(trifluoromethyl)biphenyl-3-yl]acetic acid

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Technology Process of [6-{cyclohexyl[4-(trifluoromethyl)piperidin-1-yl]methyl}-4'-(trifluoromethyl)biphenyl-3-yl]acetic acid

There total 8 articles about [6-{cyclohexyl[4-(trifluoromethyl)piperidin-1-yl]methyl}-4'-(trifluoromethyl)biphenyl-3-yl]acetic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 42058-59-3
3-hydroxy-benzeneacetic acid, methyl ester

: 1257396-75-0
[6-{cyclohexyl[4-(trifluoromethyl)piperidin-1-yl]methyl}-4'-(trifluoromethyl)biphenyl-3-yl]acetic acid

Guidance literature:: Multi-step reaction with 7 steps

1.1: triethylamine; magnesium chloride / acetonitrile / 1.92 h / 40 °C

1.2: 4 h / Reflux

2.1: pyridine; dmap / dichloromethane / 2 h / -12 - 0 °C

3.1: tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium hydrogencarbonate / 1,2-dimethoxyethane; ethanol; water / 0.17 h / 100 °C / Microwave irradiation

4.1: diethyl ether / 0.5 h / -40 - -30 °C

5.1: phosphorus tribromide / tetrahydrofuran; dichloromethane / 0.33 h / 20 °C / Inert atmosphere

6.1: potassium carbonate / N,N-dimethyl-formamide / 2 h / 20 °C

7.1: methanol; sodium hydroxide / tetrahydrofuran / 0.17 h / 100 °C

With pyridine; methanol; dmap; tetrakis(triphenylphosphine) palladium⁽⁰⁾; phosphorus tribromide; sodium hydrogencarbonate; potassium carbonate; triethylamine; sodium hydroxide; magnesium chloride; In tetrahydrofuran; 1,2-dimethoxyethane; diethyl ether; ethanol; dichloromethane; water; N,N-dimethyl-formamide; acetonitrile; 3.1: Suzuki coupling;
DOI:10.1016/j.bmcl.2011.10.047

Reference yield:

: C₂₉H₃₃F₆NO₂

: 1257396-75-0
[6-{cyclohexyl[4-(trifluoromethyl)piperidin-1-yl]methyl}-4'-(trifluoromethyl)biphenyl-3-yl]acetic acid

Guidance literature:: With methanol; sodium hydroxide; In tetrahydrofuran; at 100 ℃; for 0.166667h;
DOI:10.1016/j.bmcl.2011.10.047

Reference yield:

: 1257397-40-2
methyl 2-(4-formyl-3-hydroxyphenyl)acetate

: 1257396-75-0
[6-{cyclohexyl[4-(trifluoromethyl)piperidin-1-yl]methyl}-4'-(trifluoromethyl)biphenyl-3-yl]acetic acid

Guidance literature:: Multi-step reaction with 6 steps

1: pyridine; dmap / dichloromethane / 2 h / -12 - 0 °C

2: tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium hydrogencarbonate / 1,2-dimethoxyethane; ethanol; water / 0.17 h / 100 °C / Microwave irradiation

3: diethyl ether / 0.5 h / -40 - -30 °C

4: phosphorus tribromide / tetrahydrofuran; dichloromethane / 0.33 h / 20 °C / Inert atmosphere

5: potassium carbonate / N,N-dimethyl-formamide / 2 h / 20 °C

6: methanol; sodium hydroxide / tetrahydrofuran / 0.17 h / 100 °C

With pyridine; methanol; dmap; tetrakis(triphenylphosphine) palladium⁽⁰⁾; phosphorus tribromide; sodium hydrogencarbonate; potassium carbonate; sodium hydroxide; In tetrahydrofuran; 1,2-dimethoxyethane; diethyl ether; ethanol; dichloromethane; water; N,N-dimethyl-formamide; 2: Suzuki coupling;
DOI:10.1016/j.bmcl.2011.10.047