Methyl 2-(4-formyl-3-(trifluoromethylsulfonyloxy)phenyl)acetate

Base Information

Chemical Name:Methyl 2-(4-formyl-3-(trifluoromethylsulfonyloxy)phenyl)acetate
CAS No.:1257397-41-3
Molecular Formula:C11H9F3O6S
Molecular Weight:326.25
Hs Code.:
Mol file:1257397-41-3.mol

Synonyms:Methyl 2-(4-formyl-3-(trifluoromethylsulfonyloxy)phenyl)acetate

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Chemical Property of Methyl 2-(4-formyl-3-(trifluoromethylsulfonyloxy)phenyl)acetate

Chemical Property:

PSA：95.12000
LogP:2.52380

Purity/Quality:

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Technology Process of Methyl 2-(4-formyl-3-(trifluoromethylsulfonyloxy)phenyl)acetate

There total 2 articles about Methyl 2-(4-formyl-3-(trifluoromethylsulfonyloxy)phenyl)acetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 78.0%

: 358-23-6
trifluoromethylsulfonic anhydride

: 1257397-40-2
methyl 2-(4-formyl-3-hydroxyphenyl)acetate

: 1257397-41-3
methyl 2-(4-formyl-3-(trifluoromethylsulfonyloxy)phenyl)acetate

Guidance literature:: With pyridine; dmap; In dichloromethane; at -12 - 0 ℃; Product distribution / selectivity; Cooling with methanol-ice;

Reference yield:

: 42058-59-3
3-hydroxy-benzeneacetic acid, methyl ester

: 1257397-41-3
methyl 2-(4-formyl-3-(trifluoromethylsulfonyloxy)phenyl)acetate

Guidance literature:: Multi-step reaction with 2 steps

1.1: triethylamine; magnesium chloride / acetonitrile / 1.92 h / 40 °C

1.2: 4 h / Reflux

2.1: pyridine; dmap / dichloromethane / 2 h / -12 - 0 °C

With pyridine; dmap; triethylamine; magnesium chloride; In dichloromethane; acetonitrile;
DOI:10.1016/j.bmcl.2011.10.047

Reference yield:

: 868662-36-6
6-(trifluoromethyl)-3-pyridinylboronic acid

: 1257397-41-3
methyl 2-(4-formyl-3-(trifluoromethylsulfonyloxy)phenyl)acetate

: C₁₆H₁₂F₃NO₃

Guidance literature:: With tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium hydrogencarbonate; In 1,2-dimethoxyethane; ethanol; water; at 100 ℃; for 0.166667h; Microwave irradiation;
DOI:10.1016/j.bmcl.2011.10.047