1-[2-fluoro-6-(8-fluoroquinolin-3-yloxy)-phenyl]-2-methyl-propane-1,2-diol

Base Information

Chemical Name:1-[2-fluoro-6-(8-fluoroquinolin-3-yloxy)-phenyl]-2-methyl-propane-1,2-diol
CAS No.:1314012-49-1
Molecular Formula:C₁₉H₁₇F₂NO₃
Molecular Weight:345.346
Hs Code.:

Synonyms:1-[2-fluoro-6-(8-fluoroquinolin-3-yloxy)-phenyl]-2-methyl-propane-1,2-diol

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Chemical Property of 1-[2-fluoro-6-(8-fluoroquinolin-3-yloxy)-phenyl]-2-methyl-propane-1,2-diol

Chemical Property:

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Technology Process of 1-[2-fluoro-6-(8-fluoroquinolin-3-yloxy)-phenyl]-2-methyl-propane-1,2-diol

There total 3 articles about 1-[2-fluoro-6-(8-fluoroquinolin-3-yloxy)-phenyl]-2-methyl-propane-1,2-diol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1314012-47-9
[2-fluoro-6-(8-fluoroquinolin-3-yloxy)-phenyl]-trimethylsilyloxy-acetonitrile

: 75-16-1
methylmagnesium bromide

: 1314012-49-1
1-[2-fluoro-6-(8-fluoroquinolin-3-yloxy)-phenyl]-2-methyl-propane-1,2-diol

Guidance literature:: [2-fluoro-6-(8-fluoroquinolin-3-yloxy)-phenyl]-trimethylsilyloxy-acetonitrile; methylmagnesium bromide; In diethyl ether; at 20 ℃; Reflux;

With hydrogenchloride; In diethyl ether; water;

Reference yield:

: 437-81-0
2,6-difluorobenzaldehyde

: 1314012-49-1
1-[2-fluoro-6-(8-fluoroquinolin-3-yloxy)-phenyl]-2-methyl-propane-1,2-diol

Guidance literature:: Multi-step reaction with 3 steps

1.1: potassium carbonate / acetonitrile / 3 h / Reflux

2.1: titanium(IV) isopropylate / dichloromethane / 0 - 20 °C

2.2: 2 h / 20 °C

3.1: diethyl ether / 20 °C / Reflux

With titanium(IV) isopropylate; potassium carbonate; In diethyl ether; dichloromethane; acetonitrile;

Reference yield:

: 1261784-49-9
8-fluoro-3-hydroxyquinoline

: 1314012-49-1
1-[2-fluoro-6-(8-fluoroquinolin-3-yloxy)-phenyl]-2-methyl-propane-1,2-diol

Guidance literature:: Multi-step reaction with 3 steps

1.1: potassium carbonate / acetonitrile / 3 h / Reflux

2.1: titanium(IV) isopropylate / dichloromethane / 0 - 20 °C

2.2: 2 h / 20 °C

3.1: diethyl ether / 20 °C / Reflux

With titanium(IV) isopropylate; potassium carbonate; In diethyl ether; dichloromethane; acetonitrile;