(S)-2-[(Z)-(1S,5S)-6-(tert-Butyl-diphenyl-silanyloxy)-1-hydroxy-1,5-dimethyl-3-triphenylstannanyl-hex-3-enyl]-pyrrolidine-1-carboxylic acid tert-butyl ester

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Chemical Name:(S)-2-[(Z)-(1S,5S)-6-(tert-Butyl-diphenyl-silanyloxy)-1-hydroxy-1,5-dimethyl-3-triphenylstannanyl-hex-3-enyl]-pyrrolidine-1-carboxylic acid tert-butyl ester
CAS No.:251976-84-8
Molecular Formula:C₅₁H₆₃NO₄SiSn
Molecular Weight:900.861
Hs Code.:

(S)-2-[(Z)-(1S,5S)-6-(tert-Butyl-diphenyl-silanyloxy)-1-hydroxy-1,5-dimethyl-3-triphenylstannanyl-hex-3-enyl]-pyrrolidine-1-carboxylic acid tert-butyl ester

Synonyms:(S)-2-[(Z)-(1S,5S)-6-(tert-Butyl-diphenyl-silanyloxy)-1-hydroxy-1,5-dimethyl-3-triphenylstannanyl-hex-3-enyl]-pyrrolidine-1-carboxylic acid tert-butyl ester

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Chemical Property of (S)-2-[(Z)-(1S,5S)-6-(tert-Butyl-diphenyl-silanyloxy)-1-hydroxy-1,5-dimethyl-3-triphenylstannanyl-hex-3-enyl]-pyrrolidine-1-carboxylic acid tert-butyl ester

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Technology Process of (S)-2-[(Z)-(1S,5S)-6-(tert-Butyl-diphenyl-silanyloxy)-1-hydroxy-1,5-dimethyl-3-triphenylstannanyl-hex-3-enyl]-pyrrolidine-1-carboxylic acid tert-butyl ester

There total 1 articles about (S)-2-[(Z)-(1S,5S)-6-(tert-Butyl-diphenyl-silanyloxy)-1-hydroxy-1,5-dimethyl-3-triphenylstannanyl-hex-3-enyl]-pyrrolidine-1-carboxylic acid tert-butyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 60.0%

: 892-20-6
triphenylstannane

: 251976-83-7
tert-butyl (2S)-2-[(1S,5S)-5-{[tert-butyl(diphenyl)silyl]oxy}-1-hydroxy-1,5-dimethyl-3-hexynyl]-1-pyrrolidinecarboxylate

: C₄H₉OOCN(CH₂)3CHC(OH)(CH₃)CH₂CHC(Sn(C₆H₅)3)CH(CH₃)CH₂OSi(C₄H₉)(C₆H₅)2

: 251976-84-8
(S)-2-[(Z)-(1S,5S)-6-(tert-Butyl-diphenyl-silanyloxy)-1-hydroxy-1,5-dimethyl-3-triphenylstannanyl-hex-3-enyl]-pyrrolidine-1-carboxylic acid tert-butyl ester

Guidance literature:: With triethyl borane; In benzene; 5 days;
DOI:10.1021/ja991918x

Reference yield:

: 251976-84-8
(S)-2-[(Z)-(1S,5S)-6-(tert-Butyl-diphenyl-silanyloxy)-1-hydroxy-1,5-dimethyl-3-triphenylstannanyl-hex-3-enyl]-pyrrolidine-1-carboxylic acid tert-butyl ester

: 444929-05-9
(3Z,5S)-3-((2S)-3-{[tert-butyl(diphenyl)silyl]oxy}-2-methylpropylidene)-5-methyl-5-[(2S)-pyrrolidinyl]dihydro-2(3H)-furanone

Guidance literature:: Multi-step reaction with 3 steps

1: 83 percent / N-iodosuccinimide / CH₂Cl₂ / 0 °C

2: 97 percent / Pd(OAc)2; PPh₃; Bu₃N / hexamethylphosphoric acid triamide / 100 °C

3: CF₃CO₂H / CH₂Cl₂ / 0 °C

With palladium diacetate; N-iodo-succinimide; tributyl-amine; triphenylphosphine; trifluoroacetic acid; In N,N,N,N,N,N-hexamethylphosphoric triamide; dichloromethane; 1: Substitution / 2: cyclization; carbonylation / 3: acidolysis;
DOI:10.1021/ja991918x

Reference yield:

: 251976-84-8
(S)-2-[(Z)-(1S,5S)-6-(tert-Butyl-diphenyl-silanyloxy)-1-hydroxy-1,5-dimethyl-3-triphenylstannanyl-hex-3-enyl]-pyrrolidine-1-carboxylic acid tert-butyl ester

: 251976-88-2
(6Z,8S,8aS)-6-((2S)-3-{[tert-butyl(diphenyl)silyl]oxy}-2-methylpropylidene)-8-methyloctahydro-8-indolizinol

Guidance literature:: Multi-step reaction with 5 steps

1: 83 percent / N-iodosuccinimide / CH₂Cl₂ / 0 °C

2: 97 percent / Pd(OAc)2; PPh₃; Bu₃N / hexamethylphosphoric acid triamide / 100 °C

3: CF₃CO₂H / CH₂Cl₂ / 0 °C

4: DIBALH / toluene / -30 °C

5: 85 percent / CBr₄; PPh₃ / CH₂Cl₂ / 0.5 h / 0 °C

With palladium diacetate; N-iodo-succinimide; tributyl-amine; carbon tetrabromide; diisobutylaluminium hydride; triphenylphosphine; trifluoroacetic acid; In N,N,N,N,N,N-hexamethylphosphoric triamide; dichloromethane; toluene; 1: Substitution / 2: cyclization; carbonylation / 3: acidolysis / 4: Reduction / 5: cyclization; dehydration;
DOI:10.1021/ja991918x