1-ethyl 2-methyl 3-amino-4-<2-cyano-1-(2,3,5-trichlorophenyl)ethyl>-1H-pyrrole-1,2-dicarboxylate

Base Information

Chemical Name:1-ethyl 2-methyl 3-amino-4-<2-cyano-1-(2,3,5-trichlorophenyl)ethyl>-1H-pyrrole-1,2-dicarboxylate
CAS No.:135851-13-7
Molecular Formula:C₁₈H₁₆Cl₃N₃O₄
Molecular Weight:444.702
Hs Code.:

Synonyms:1-ethyl 2-methyl 3-amino-4-<2-cyano-1-(2,3,5-trichlorophenyl)ethyl>-1H-pyrrole-1,2-dicarboxylate

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Chemical Property of 1-ethyl 2-methyl 3-amino-4-<2-cyano-1-(2,3,5-trichlorophenyl)ethyl>-1H-pyrrole-1,2-dicarboxylate

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Technology Process of 1-ethyl 2-methyl 3-amino-4-<2-cyano-1-(2,3,5-trichlorophenyl)ethyl>-1H-pyrrole-1,2-dicarboxylate

There total 4 articles about 1-ethyl 2-methyl 3-amino-4-<2-cyano-1-(2,3,5-trichlorophenyl)ethyl>-1H-pyrrole-1,2-dicarboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 74.7%

: 541-41-3
chloroformic acid ethyl ester

: 151433-89-5
methyl N-<2,4-dicyano-3-(2,3,5-trichlorophenyl)-1-butenyl>glycine

: 135851-13-7
1-ethyl 2-methyl 3-amino-4-<2-cyano-1-(2,3,5-trichlorophenyl)ethyl>-1H-pyrrole-1,2-dicarboxylate

Guidance literature:: With 2,6-dichloro-benzonitrile; In dichloromethane; 1.) 0 deg C, 1 h, 2.) RT, 48 h;
DOI:10.1021/jm00076a004

Reference yield:

: 56961-75-2
2,3,5-trichlorobenzaldehyde

: 135851-13-7
1-ethyl 2-methyl 3-amino-4-<2-cyano-1-(2,3,5-trichlorophenyl)ethyl>-1H-pyrrole-1,2-dicarboxylate

Guidance literature:: Multi-step reaction with 4 steps

1: 73 percent / piperidine / pyridine / 8 h

2: NaH / tetrahydrofuran / 1.) from 5 to 10 deg C, 2 h, 2.) RT, overnight

3: 75 percent / NaOAc / H₂O; methanol / 22 h / Ambient temperature

4: 74.7 percent / DBN / CH₂Cl₂ / 1.) 0 deg C, 1 h, 2.) RT, 48 h

With piperidine; 2,6-dichloro-benzonitrile; sodium acetate; sodium hydride; In tetrahydrofuran; pyridine; methanol; dichloromethane; water;
DOI:10.1021/jm00076a004

Reference yield:

: 135851-09-1
3-(2,3,5-trichlorophenyl)pentanedinitrile

: 135851-13-7
1-ethyl 2-methyl 3-amino-4-<2-cyano-1-(2,3,5-trichlorophenyl)ethyl>-1H-pyrrole-1,2-dicarboxylate

Guidance literature:: Multi-step reaction with 3 steps

1: NaH / tetrahydrofuran / 1.) from 5 to 10 deg C, 2 h, 2.) RT, overnight

2: 75 percent / NaOAc / H₂O; methanol / 22 h / Ambient temperature

3: 74.7 percent / DBN / CH₂Cl₂ / 1.) 0 deg C, 1 h, 2.) RT, 48 h

With 2,6-dichloro-benzonitrile; sodium acetate; sodium hydride; In tetrahydrofuran; methanol; dichloromethane; water;
DOI:10.1021/jm00076a004