N-cyclopropyl-4-((3-(4-fluorophenoxy)-5-sulfamoylphenyl)amino)-7-(pyridin-2-yl)quinoline-3-sulfonamide

Base Information

Chemical Name:N-cyclopropyl-4-((3-(4-fluorophenoxy)-5-sulfamoylphenyl)amino)-7-(pyridin-2-yl)quinoline-3-sulfonamide
CAS No.:1445879-79-7
Molecular Formula:C₂₉H₂₄FN₅O₅S₂
Molecular Weight:605.67
Hs Code.:

Synonyms:N-cyclopropyl-4-((3-(4-fluorophenoxy)-5-sulfamoylphenyl)amino)-7-(pyridin-2-yl)quinoline-3-sulfonamide

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Chemical Property of N-cyclopropyl-4-((3-(4-fluorophenoxy)-5-sulfamoylphenyl)amino)-7-(pyridin-2-yl)quinoline-3-sulfonamide

Chemical Property:

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Technology Process of N-cyclopropyl-4-((3-(4-fluorophenoxy)-5-sulfamoylphenyl)amino)-7-(pyridin-2-yl)quinoline-3-sulfonamide

There total 12 articles about N-cyclopropyl-4-((3-(4-fluorophenoxy)-5-sulfamoylphenyl)amino)-7-(pyridin-2-yl)quinoline-3-sulfonamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 109-04-6
2-bromo-pyridine

: 1445880-88-5
3-(N-cyclopropylsulfamoyl)-4-(3-(4-fluorophenoxy)-5 sulfamoylphenylamino)quinolin-7-ylboronic acid

: 1445879-79-7
N-cyclopropyl-4-((3-(4-fluorophenoxy)-5-sulfamoylphenyl)amino)-7-(pyridin-2-yl)quinoline-3-sulfonamide

Guidance literature:: With dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; potassium carbonate; In 1,4-dioxane; water; at 80 ℃; for 1h; Inert atmosphere;

Reference yield:

: 82121-06-0
4-hydroxy-7-bromoquinoline

: 1445879-79-7
N-cyclopropyl-4-((3-(4-fluorophenoxy)-5-sulfamoylphenyl)amino)-7-(pyridin-2-yl)quinoline-3-sulfonamide

Guidance literature:: Multi-step reaction with 6 steps

1: chlorosulfonic acid / 18 h / 100 °C

2: trichlorophosphate / 3 h / Reflux

3: triethylamine / dichloromethane / 1 h / 0 °C

4: ethanol / 2 h / Reflux

5: dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; potassium acetate; bis(pinacol)diborane / 1,4-dioxane / 24 h / 100 °C

6: dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; potassium carbonate / 1,4-dioxane; water / 1 h / 80 °C / Inert atmosphere

With chlorosulfonic acid; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; potassium acetate; potassium carbonate; triethylamine; bis(pinacol)diborane; trichlorophosphate; In 1,4-dioxane; ethanol; dichloromethane; water;

Reference yield:

: 1445879-89-9
7-bromo-4-chloro-N-cyclopropyl-3-quinolinesulfonamide

: 1445879-79-7
N-cyclopropyl-4-((3-(4-fluorophenoxy)-5-sulfamoylphenyl)amino)-7-(pyridin-2-yl)quinoline-3-sulfonamide

Guidance literature:: Multi-step reaction with 3 steps

1: ethanol / 2 h / Reflux

2: dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; potassium acetate; bis(pinacol)diborane / 1,4-dioxane / 24 h / 100 °C

3: dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; potassium carbonate / 1,4-dioxane; water / 1 h / 80 °C / Inert atmosphere

With dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; potassium acetate; potassium carbonate; bis(pinacol)diborane; In 1,4-dioxane; ethanol; water;