3-(N-cyclopropylsulfamoyl)-4-(3-(4-fluorophenoxy)-5 sulfamoylphenylamino)quinolin-7-ylboronic acid

Base Information

Chemical Name:3-(N-cyclopropylsulfamoyl)-4-(3-(4-fluorophenoxy)-5 sulfamoylphenylamino)quinolin-7-ylboronic acid
CAS No.:1445880-88-5
Molecular Formula:C₂₄H₂₂BFN₄O₇S₂
Molecular Weight:572.403
Hs Code.:

Synonyms:3-(N-cyclopropylsulfamoyl)-4-(3-(4-fluorophenoxy)-5 sulfamoylphenylamino)quinolin-7-ylboronic acid

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Chemical Property of 3-(N-cyclopropylsulfamoyl)-4-(3-(4-fluorophenoxy)-5 sulfamoylphenylamino)quinolin-7-ylboronic acid

Chemical Property:

Purity/Quality:

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Technology Process of 3-(N-cyclopropylsulfamoyl)-4-(3-(4-fluorophenoxy)-5 sulfamoylphenylamino)quinolin-7-ylboronic acid

There total 11 articles about 3-(N-cyclopropylsulfamoyl)-4-(3-(4-fluorophenoxy)-5 sulfamoylphenylamino)quinolin-7-ylboronic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1445880-81-8
7-bromo-N-cyclopropyl-4-(3-(4-fluorophenoxy)-5-sulfamoylphenylamino)quinoline-3-sulfonamide

: 1445880-88-5
3-(N-cyclopropylsulfamoyl)-4-(3-(4-fluorophenoxy)-5 sulfamoylphenylamino)quinolin-7-ylboronic acid

Guidance literature:: With dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; potassium acetate; bis(pinacol)diborane; In 1,4-dioxane; at 100 ℃; for 24h;

Reference yield:

: 82121-06-0
4-hydroxy-7-bromoquinoline

: 1445880-88-5
3-(N-cyclopropylsulfamoyl)-4-(3-(4-fluorophenoxy)-5 sulfamoylphenylamino)quinolin-7-ylboronic acid

Guidance literature:: Multi-step reaction with 5 steps

1: chlorosulfonic acid / 18 h / 100 °C

2: trichlorophosphate / 3 h / Reflux

3: triethylamine / dichloromethane / 1 h / 0 °C

4: ethanol / 2 h / Reflux

5: dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; potassium acetate; bis(pinacol)diborane / 1,4-dioxane / 24 h / 100 °C

With chlorosulfonic acid; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; potassium acetate; triethylamine; bis(pinacol)diborane; trichlorophosphate; In 1,4-dioxane; ethanol; dichloromethane;

Reference yield:

: 1445879-89-9
7-bromo-4-chloro-N-cyclopropyl-3-quinolinesulfonamide

: 1445880-88-5
3-(N-cyclopropylsulfamoyl)-4-(3-(4-fluorophenoxy)-5 sulfamoylphenylamino)quinolin-7-ylboronic acid

Guidance literature:: Multi-step reaction with 2 steps

1: ethanol / 2 h / Reflux

2: dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; potassium acetate; bis(pinacol)diborane / 1,4-dioxane / 24 h / 100 °C

With dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; potassium acetate; bis(pinacol)diborane; In 1,4-dioxane; ethanol;