5-amino-N-(5-amino-1-(4-methoxybenzyl)-1H-pyrazol-4-yl)-2-methylbenzamide

Base Information

Chemical Name:5-amino-N-(5-amino-1-(4-methoxybenzyl)-1H-pyrazol-4-yl)-2-methylbenzamide
CAS No.:1292281-66-3
Molecular Formula:C₁₉H₂₁N₅O₂
Molecular Weight:351.408
Hs Code.:

Synonyms:5-amino-N-(5-amino-1-(4-methoxybenzyl)-1H-pyrazol-4-yl)-2-methylbenzamide

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Chemical Property of 5-amino-N-(5-amino-1-(4-methoxybenzyl)-1H-pyrazol-4-yl)-2-methylbenzamide

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Technology Process of 5-amino-N-(5-amino-1-(4-methoxybenzyl)-1H-pyrazol-4-yl)-2-methylbenzamide

There total 4 articles about 5-amino-N-(5-amino-1-(4-methoxybenzyl)-1H-pyrazol-4-yl)-2-methylbenzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1292281-64-1
N-(5-amino-1-(4-methoxybenzyl)-1H-pyrazol-4-yl)-2-methyl-5-nitrobenzamide

: 1292281-66-3
5-amino-N-(5-amino-1-(4-methoxybenzyl)-1H-pyrazol-4-yl)-2-methylbenzamide

Guidance literature:: N-(5-amino-1-(4-methoxybenzyl)-1H-pyrazol-4-yl)-2-methyl-5-nitrobenzamide; With tin(II) chloride dihdyrate; In ethanol; at 80 ℃; for 0.75h;

With water; sodium hydrogencarbonate; In ethanol; at 20 ℃; pH=7 - 8;
DOI:10.1016/j.bmc.2011.01.067

Reference yield:

: 1236202-77-9
1-(4-methoxybenzyl)-4-nitroso-1H-pyrazol-5-amine

: 1292281-66-3
5-amino-N-(5-amino-1-(4-methoxybenzyl)-1H-pyrazol-4-yl)-2-methylbenzamide

Guidance literature:: Multi-step reaction with 3 steps

1.1: hydrogenchloride; tin(II) chloride dihdyrate / ethanol; water / 0.75 h / 80 °C

1.2: pH 7 - 8 / Cooling with ice

2.1: benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine / N,N-dimethyl-formamide / 4 h / 80 °C

3.1: tin(II) chloride dihdyrate / ethanol / 0.75 h / 80 °C

3.2: 20 °C / pH 7 - 8

With hydrogenchloride; tin(II) chloride dihdyrate; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; In ethanol; water; N,N-dimethyl-formamide;
DOI:10.1016/j.bmc.2011.01.067

Reference yield:

: 4,5-diamino-1-(4'-methoxybenzyl)-1H-pyrazole

: 1292281-66-3
5-amino-N-(5-amino-1-(4-methoxybenzyl)-1H-pyrazol-4-yl)-2-methylbenzamide

Guidance literature:: Multi-step reaction with 2 steps

1.1: benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine / N,N-dimethyl-formamide / 4 h / 80 °C

2.1: tin(II) chloride dihdyrate / ethanol / 0.75 h / 80 °C

2.2: 20 °C / pH 7 - 8

With tin(II) chloride dihdyrate; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; In ethanol; N,N-dimethyl-formamide;
DOI:10.1016/j.bmc.2011.01.067