N-(5-amino-1-(4-methoxybenzyl)-1H-pyrazol-4-yl)-2-methyl-5-nitrobenzamide

Base Information

Chemical Name:N-(5-amino-1-(4-methoxybenzyl)-1H-pyrazol-4-yl)-2-methyl-5-nitrobenzamide
CAS No.:1292281-64-1
Molecular Formula:C₁₉H₁₉N₅O₄
Molecular Weight:381.391
Hs Code.:

Synonyms:N-(5-amino-1-(4-methoxybenzyl)-1H-pyrazol-4-yl)-2-methyl-5-nitrobenzamide

Suppliers and Price of N-(5-amino-1-(4-methoxybenzyl)-1H-pyrazol-4-yl)-2-methyl-5-nitrobenzamide

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Total 1 raw suppliers

Chemical Property of N-(5-amino-1-(4-methoxybenzyl)-1H-pyrazol-4-yl)-2-methyl-5-nitrobenzamide

Chemical Property:

Purity/Quality:: 98% ^*data from raw suppliers

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Technology Process of N-(5-amino-1-(4-methoxybenzyl)-1H-pyrazol-4-yl)-2-methyl-5-nitrobenzamide

There total 3 articles about N-(5-amino-1-(4-methoxybenzyl)-1H-pyrazol-4-yl)-2-methyl-5-nitrobenzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.7%

: 4,5-diamino-1-(4'-methoxybenzyl)-1H-pyrazole

: 1975-52-6
5-nitro-o-toluic acid

: 1292281-64-1
N-(5-amino-1-(4-methoxybenzyl)-1H-pyrazol-4-yl)-2-methyl-5-nitrobenzamide

Guidance literature:: With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; In N,N-dimethyl-formamide; at 80 ℃; for 4h;
DOI:10.1016/j.bmc.2011.01.067

Reference yield:

: 1236202-77-9
1-(4-methoxybenzyl)-4-nitroso-1H-pyrazol-5-amine

: 1292281-64-1
N-(5-amino-1-(4-methoxybenzyl)-1H-pyrazol-4-yl)-2-methyl-5-nitrobenzamide

Guidance literature:: Multi-step reaction with 2 steps

1.1: hydrogenchloride; tin(II) chloride dihdyrate / ethanol; water / 0.75 h / 80 °C

1.2: pH 7 - 8 / Cooling with ice

2.1: benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine / N,N-dimethyl-formamide / 4 h / 80 °C

With hydrogenchloride; tin(II) chloride dihdyrate; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; In ethanol; water; N,N-dimethyl-formamide;
DOI:10.1016/j.bmc.2011.01.067

Reference yield:

: 2011-48-5,412327-07-2
1-(4-methoxybenzyl)hydrazine hydrochloride

: 1292281-64-1
N-(5-amino-1-(4-methoxybenzyl)-1H-pyrazol-4-yl)-2-methyl-5-nitrobenzamide

Guidance literature:: Multi-step reaction with 3 steps

1.1: hydrogenchloride; sodium nitrite / methanol; water / 1 h / -15 - -5 °C

1.2: 2 h / 0 °C

2.1: hydrogenchloride; tin(II) chloride dihdyrate / ethanol; water / 0.75 h / 80 °C

2.2: pH 7 - 8 / Cooling with ice

3.1: benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine / N,N-dimethyl-formamide / 4 h / 80 °C

With hydrogenchloride; tin(II) chloride dihdyrate; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; sodium nitrite; In methanol; ethanol; water; N,N-dimethyl-formamide;
DOI:10.1016/j.bmc.2011.01.067