Thiophene-3-carboxylic acid [5-(2-fluoro-phenyl)-2,3-dihydro-1H-benzo[e][1,4]diazepin-3-ylmethyl]-amide

Base Information

Chemical Name:Thiophene-3-carboxylic acid [5-(2-fluoro-phenyl)-2,3-dihydro-1H-benzo[e][1,4]diazepin-3-ylmethyl]-amide
CAS No.:103343-77-7
Molecular Formula:C₂₁H₁₈FN₃OS
Molecular Weight:379.458
Hs Code.:

Synonyms:Thiophene-3-carboxylic acid [5-(2-fluoro-phenyl)-2,3-dihydro-1H-benzo[e][1,4]diazepin-3-ylmethyl]-amide

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Chemical Property of Thiophene-3-carboxylic acid [5-(2-fluoro-phenyl)-2,3-dihydro-1H-benzo[e][1,4]diazepin-3-ylmethyl]-amide

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Technology Process of Thiophene-3-carboxylic acid [5-(2-fluoro-phenyl)-2,3-dihydro-1H-benzo[e][1,4]diazepin-3-ylmethyl]-amide

There total 4 articles about Thiophene-3-carboxylic acid [5-(2-fluoro-phenyl)-2,3-dihydro-1H-benzo[e][1,4]diazepin-3-ylmethyl]-amide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 49.0%

: 41507-35-1
3-thiophene carboxylic acid chloride

: 123903-97-9
1,3-dihydro-3(R,S)-(aminomethyl)-5-(2'-fluorophenyl)-2H-1,4-benzodiazepine

: 103343-77-7
Thiophene-3-carboxylic acid [5-(2-fluoro-phenyl)-2,3-dihydro-1H-benzo[e][1,4]diazepin-3-ylmethyl]-amide

Guidance literature:: With triethylamine; In tetrahydrofuran; at 0 - 23 ℃;
DOI:10.1021/jm00163a069

Reference yield:

: 103343-37-9
1,3-dihydro-5-(2'-fluorophenyl)-3(R,S)-(aminomethyl)-2H-1,4-benzodiazepin-2-one

: 103343-77-7
Thiophene-3-carboxylic acid [5-(2-fluoro-phenyl)-2,3-dihydro-1H-benzo[e][1,4]diazepin-3-ylmethyl]-amide

Guidance literature:: Multi-step reaction with 5 steps

1: 97 percent / 4-(dimethylamino)pyridine / CH₂Cl₂ / 0 - 23 °C / overnight

2: 95 percent / Lawesson's reagent / toluene / 1.5 h / Heating

3: 50 percent / W-2 Raney nickel / ethanol / 50 h

4: hydrogen bromide / CH₂Cl₂ / 0 - 20 °C

5: 49 percent / triethylamine / tetrahydrofuran / 0 - 23 °C

With Lawessons reagent; dmap; hydrogen bromide; triethylamine; W-2 Raney nickel; In tetrahydrofuran; ethanol; dichloromethane; toluene;
DOI:10.1021/jm00163a069

Reference yield:

: 103343-35-7
N-(2'-Fluorobenzoylphenyl)-2,3-diphthalylaminopropionylamide

: 103343-77-7
Thiophene-3-carboxylic acid [5-(2-fluoro-phenyl)-2,3-dihydro-1H-benzo[e][1,4]diazepin-3-ylmethyl]-amide

Guidance literature:: Multi-step reaction with 6 steps

1: 90 percent / hydrazine / methanol / 14 h / 23 °C

2: 97 percent / 4-(dimethylamino)pyridine / CH₂Cl₂ / 0 - 23 °C / overnight

3: 95 percent / Lawesson's reagent / toluene / 1.5 h / Heating

4: 50 percent / W-2 Raney nickel / ethanol / 50 h

5: hydrogen bromide / CH₂Cl₂ / 0 - 20 °C

6: 49 percent / triethylamine / tetrahydrofuran / 0 - 23 °C

With Lawessons reagent; dmap; hydrogen bromide; triethylamine; hydrazine; W-2 Raney nickel; In tetrahydrofuran; methanol; ethanol; dichloromethane; toluene;
DOI:10.1021/jm00163a069