5-(4-chloro-3-methylphenyl)-1-(4-methylbenzyl)-1H-pyrrole-3-carboxylic acid

Base Information

Chemical Name:5-(4-chloro-3-methylphenyl)-1-(4-methylbenzyl)-1H-pyrrole-3-carboxylic acid
CAS No.:1480377-53-4
Molecular Formula:C₂₀H₁₈ClNO₂
Molecular Weight:339.821
Hs Code.:

Synonyms:5-(4-chloro-3-methylphenyl)-1-(4-methylbenzyl)-1H-pyrrole-3-carboxylic acid

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Chemical Property of 5-(4-chloro-3-methylphenyl)-1-(4-methylbenzyl)-1H-pyrrole-3-carboxylic acid

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Technology Process of 5-(4-chloro-3-methylphenyl)-1-(4-methylbenzyl)-1H-pyrrole-3-carboxylic acid

There total 12 articles about 5-(4-chloro-3-methylphenyl)-1-(4-methylbenzyl)-1H-pyrrole-3-carboxylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 83.5%

: methyl 5-(4-chloro-3-methylphenyl)-1-(4-methylbenzyl)-1H-pyrrole-3-carboxylate

: 1480377-53-4
5-(4-chloro-3-methylphenyl)-1-(4-methylbenzyl)-1H-pyrrole-3-carboxylic acid

Guidance literature:: With water; sodium hydroxide; In ethanol; for 12h; Reflux;
DOI:10.1016/j.ejmech.2015.06.057

Reference yield: 75.0%

: 1449692-02-7
5-(4-chloro-3-methyl-phenyl)-1-(4-methyl-benzyl)-1H-pyrrole-3-carboxylic acid ethyl ester

: 1480377-53-4
5-(4-chloro-3-methylphenyl)-1-(4-methylbenzyl)-1H-pyrrole-3-carboxylic acid

Guidance literature:: With sodium hydroxide; In ethanol; at 20 - 60 ℃; for 96h; Inert atmosphere;
DOI:10.1021/jm400070u

Reference yield:

: 1449691-99-9
N-[(4-chloro-3-methyl-phenyl)-(toluene-4-sulfonyl)methyl]formamide

: 1480377-53-4
5-(4-chloro-3-methylphenyl)-1-(4-methylbenzyl)-1H-pyrrole-3-carboxylic acid

Guidance literature:: Multi-step reaction with 4 steps

1.1: trichlorophosphate / tetrahydrofuran / 0.08 h / 20 °C / Inert atmosphere

1.2: 0.12 h / 3 - 8 °C

2.1: sodium hydride / mineral oil; diethyl ether; dimethyl sulfoxide / 2.25 h / 0 - 10 °C / Inert atmosphere

3.1: sodium hydride / mineral oil; N,N-dimethyl-formamide / 0.25 h / Inert atmosphere

3.2: 2 h / Inert atmosphere

4.1: sodium hydroxide / ethanol / 96 h / 20 - 60 °C / Inert atmosphere

With sodium hydride; sodium hydroxide; trichlorophosphate; In tetrahydrofuran; diethyl ether; ethanol; dimethyl sulfoxide; N,N-dimethyl-formamide; mineral oil;
DOI:10.1021/jm400070u