(2S,4S,5S)-5-(t-butoxycarbonyl)amino-6-cyclohexyl-4-hydroxy-2-isopropyl-N-butylhexanamide

Base Information

Chemical Name:(2S,4S,5S)-5-(t-butoxycarbonyl)amino-6-cyclohexyl-4-hydroxy-2-isopropyl-N-butylhexanamide
CAS No.:124032-35-5
Molecular Formula:C₂₄H₄₆N₂O₄
Molecular Weight:426.64
Hs Code.:

Synonyms:(2S,4S,5S)-5-(t-butoxycarbonyl)amino-6-cyclohexyl-4-hydroxy-2-isopropyl-N-butylhexanamide

Suppliers and Price of (2S,4S,5S)-5-(t-butoxycarbonyl)amino-6-cyclohexyl-4-hydroxy-2-isopropyl-N-butylhexanamide

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of (2S,4S,5S)-5-(t-butoxycarbonyl)amino-6-cyclohexyl-4-hydroxy-2-isopropyl-N-butylhexanamide

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of (2S,4S,5S)-5-(t-butoxycarbonyl)amino-6-cyclohexyl-4-hydroxy-2-isopropyl-N-butylhexanamide

There total 22 articles about (2S,4S,5S)-5-(t-butoxycarbonyl)amino-6-cyclohexyl-4-hydroxy-2-isopropyl-N-butylhexanamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

: 124032-36-6
(3S,5S)-5-[(1S)-1-(t-butoxycarbonyl)amino-2-cyclohexylethyl]-3-isopropyldihydrofuran-2(3H)-one

: 109-73-9,85404-21-3
N-butylamine

: 124032-35-5
(2S,4S,5S)-5-(t-butoxycarbonyl)amino-6-cyclohexyl-4-hydroxy-2-isopropyl-N-butylhexanamide

Guidance literature:

Reference yield: 89.0%

: 129921-94-4
N-butyl-2-(S)-((3-(tert-butyloxycarbonyl)-2,2-dimethyl-4(S)-(cyclohexylmethyl)-5(S)-oxazolidinyl)methyl)-3-methylbutanamide

: 124032-35-5
(2S,4S,5S)-5-(t-butoxycarbonyl)amino-6-cyclohexyl-4-hydroxy-2-isopropyl-N-butylhexanamide

Guidance literature:: With hydrogenchloride; acetic acid; In tetrahydrofuran;
DOI:10.1016/S0040-4039(00)91634-4

Reference yield:

: 98105-42-1
(S)-2-(t-butoxycarbonylamino)-3-cyclohexyl-1-propanal

: 124032-35-5
(2S,4S,5S)-5-(t-butoxycarbonyl)amino-6-cyclohexyl-4-hydroxy-2-isopropyl-N-butylhexanamide

Guidance literature:: Multi-step reaction with 9 steps

1: 1) n-BuLi, 2) ZnBr₂ / 1) THF, 2) THF

2: 78 percent / PpTSA / CH₂Cl₂

3: 80 percent / RuCl₃*H₂O, NaIO₄ / acetonitrile; CCl₄; H₂O

4: 80 percent / 1,1'-carbonyldiimidazole, Et₃N / tetrahydrofuran

5: 95 percent / LiAlH₄ / diethyl ether

6: 81 percent / KN(TMS)2 / tetrahydrofuran

7: H₂ / Rh/Al₂O₃ / tetrahydrofuran

8: 10percent HCl, AcOH / tetrahydrofuran

9: Me₃Al / 1,2-dichloro-ethane

With hydrogenchloride; ruthenium trichloride; sodium periodate; lithium aluminium tetrahydride; n-butyllithium; hydrogen; trimethylaluminum; pyridinium p-toluenesulfonate; potassium hexamethylsilazane; acetic acid; triethylamine; 1,1'-carbonyldiimidazole; zinc dibromide; Rh/Al₂O₃; In tetrahydrofuran; tetrachloromethane; diethyl ether; dichloromethane; water; 1,2-dichloro-ethane; acetonitrile;
DOI:10.1016/S0040-4039(00)91634-4