(2S,4S,5S)-5-amino-6-cyclohexyl-4-hydroxy-2-isopropyl hexanoic acid n-butyl amide

Base Information

• Chemical Name: (2S,4S,5S)-5-amino-6-cyclohexyl-4-hydroxy-2-isopropyl hexanoic acid n-butyl amide
• CAS No.: 105852-64-0
• Molecular Formula: C₁₉H₃₈N₂O₂
• Molecular Weight: 326.523
• Mol file: 105852-64-0.mol

Synonyms:(2S,4S,5S)-5-amino-6-cyclohexyl-4-hydroxy-2-isopropyl hexanoic acid n-butyl amide

Chemical Property of (2S,4S,5S)-5-amino-6-cyclohexyl-4-hydroxy-2-isopropyl hexanoic acid n-butyl amide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (2S,4S,5S)-5-amino-6-cyclohexyl-4-hydroxy-2-isopropyl hexanoic acid n-butyl amide

There total 61 articles about (2S,4S,5S)-5-amino-6-cyclohexyl-4-hydroxy-2-isopropyl hexanoic acid n-butyl amide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

(2S)-2-[(4S,5S)-3-benzyloxycarbonyl-4-cyclohexylmethyl-2,2-dimethyl-1,3-oxazolidin-5-yl]methyl-N-butyl-3-methylbutanamide (105852-65-1) → (2S,4S,5S)-5-amino-6-cyclohexyl-4-hydroxy-2-isopropyl hexanoic acid n-butyl amide (105852-64-0)

Guidance literature:

With hydrogen; palladium on activated charcoal; In methanol; water; at 25 ℃; for 4h;

DOI:10.1021/jm00117a027

Reference yield: 94.2%

(2S,4S,5S)-N-butyl-5-azido-6-cyclohexyl-4-hydroxy-2-(1-methylethyl)hexanamide → (2S,4S,5S)-5-amino-6-cyclohexyl-4-hydroxy-2-isopropyl hexanoic acid n-butyl amide (105852-64-0)

Guidance literature:

With hydrogen; palladium on activated charcoal; In methanol; for 2h; under 760 Torr;

DOI:10.1021/jo00266a034

Reference yield: 84.0%

N-butyl-2-(S)-((3-(tert-butyloxycarbonyl)-2,2-dimethyl-4(S)-(cyclohexylmethyl)-5(S)-oxazolidinyl)methyl)-3-methylbutanamide (129921-94-4) → (2S,4S,5S)-5-amino-6-cyclohexyl-4-hydroxy-2-isopropyl hexanoic acid n-butyl amide (105852-64-0)

Guidance literature:

With hydrogenchloride; In 1,4-dioxane;

DOI:10.1016/S0040-4039(00)91634-4

upstream raw materials:

(2S)-2-[(4S,5S)-3-benzyloxycarbonyl-4-cyclohexylmethyl-2,2-dimethyl-1,3-oxazolidin-5-yl]methyl-N-butyl-3-methylbutanamide

N-butyl-2-(S)-((3-(tert-butyloxycarbonyl)-2,2-dimethyl-4(S)-(cyclohexylmethyl)-5(S)-oxazolidinyl)methyl)-3-methylbutanamide

(2S,4S,5S)-5-(t-butoxycarbonyl)amino-6-cyclohexyl-4-hydroxy-2-isopropyl-N-butylhexanamide

methyl 3-methylbutanoate

Downstream raw materials:

[(S)-1-((1S,2S,4S)-4-Butylcarbamoyl-1-cyclohexylmethyl-2-hydroxy-5-methyl-hexylcarbamoyl)-2-(1H-imidazol-4-yl)-ethyl]-carbamic acid tert-butyl ester

4(S)-butyl-4(S)-<(tert-butyloxycarbonyl)amino>-N-<4(S)-<(butylamino)carbonyl>-1(S)-(cyclohexylmethyl)-2(S)-hydroxy-5-methylhexyl>-1,3,4,5-tetrahydro-3-oxo-2H-2-benzazepine-2-acetamide

N-<(1,1-dimethylethoxy)carbonyl>-L-phenylalanyl-N-<4(S)-<(butylamino)carbonyl>-1(S)-(cyclohexylmethyl)-2(S)-hydroxy-5-methylhexyl>-L-norleucinamide

4(S)-(acetylamino)-α(S)-butyl-N-<4(S)-<(butylamino)carbonyl>-1(S)-(cyclohexylmethyl)-2(S)-hydroxy-5-methylhexyl>-1,3,4,5-tetrahydro-3-oxo-2H-2-benzazepine-2-acetamide