[(8R,9S,10S)-9-(4-bromophenyl)-6-[(2-nitrophenyl)sulfonyl]-1,6-diazabicyclo[6.2.0]decan-10-yl]methanol

Base Information

Chemical Name:[(8R,9S,10S)-9-(4-bromophenyl)-6-[(2-nitrophenyl)sulfonyl]-1,6-diazabicyclo[6.2.0]decan-10-yl]methanol
CAS No.:1393810-30-4
Molecular Formula:C₂₁H₂₄BrN₃O₅S
Molecular Weight:510.409
Hs Code.:

Synonyms:[(8R,9S,10S)-9-(4-bromophenyl)-6-[(2-nitrophenyl)sulfonyl]-1,6-diazabicyclo[6.2.0]decan-10-yl]methanol

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Chemical Property of [(8R,9S,10S)-9-(4-bromophenyl)-6-[(2-nitrophenyl)sulfonyl]-1,6-diazabicyclo[6.2.0]decan-10-yl]methanol

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Technology Process of [(8R,9S,10S)-9-(4-bromophenyl)-6-[(2-nitrophenyl)sulfonyl]-1,6-diazabicyclo[6.2.0]decan-10-yl]methanol

There total 15 articles about [(8R,9S,10S)-9-(4-bromophenyl)-6-[(2-nitrophenyl)sulfonyl]-1,6-diazabicyclo[6.2.0]decan-10-yl]methanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 52.0%

: C₄₀H₃₆BrN₃O₅S

: 1393810-30-4
[(8R,9S,10S)-9-(4-bromophenyl)-6-[(2-nitrophenyl)sulfonyl]-1,6-diazabicyclo[6.2.0]decan-10-yl]methanol

Guidance literature:: C₄₀H₃₆BrN₃O₅S; With trifluoroacetic acid; In dichloromethane; for 2h;

With Wilkinson's catalyst; hydrogen; In tetrahydrofuran; for 6h; under 760.051 Torr;

Reference yield:

: C₂₁H₂₂BrN₃O₅S

: 1393810-30-4
[(8R,9S,10S)-9-(4-bromophenyl)-6-[(2-nitrophenyl)sulfonyl]-1,6-diazabicyclo[6.2.0]decan-10-yl]methanol

Guidance literature:: With 2-nitrobenzenesulfonyl hydrazide; triethylamine; In tetrahydrofuran; at 40 ℃; for 6h; Inert atmosphere;
DOI:10.1021/jo300974j

Reference yield:

: 1393809-90-9
(2S,3S,4R)-1-allyl-3-(4-bromophenyl)-2-((trityloxy)methyl)azetidine-4-carbonitrile

: 1393810-30-4
[(8R,9S,10S)-9-(4-bromophenyl)-6-[(2-nitrophenyl)sulfonyl]-1,6-diazabicyclo[6.2.0]decan-10-yl]methanol

Guidance literature:: Multi-step reaction with 6 steps

1.1: diisobutylaluminium hydride / dichloromethane / 2 h / 0 - 20 °C / Inert atmosphere

1.2: Inert atmosphere

2.1: 2,6-dimethylpyridine / dichloromethane / 3 h / 0 - 20 °C

3.1: potassium carbonate / N,N-dimethyl-formamide / 2 h / 0 °C / Inert atmosphere

4.1: Grubbs catalyst first generation / benzene / 24 h / 50 °C / Inert atmosphere

5.1: trifluoroacetic acid / dichloromethane / 0 °C / Inert atmosphere

6.1: 2-nitrobenzenesulfonyl hydrazide; triethylamine / tetrahydrofuran / 6 h / 40 °C / Inert atmosphere

With 2,6-dimethylpyridine; Grubbs catalyst first generation; 2-nitrobenzenesulfonyl hydrazide; diisobutylaluminium hydride; potassium carbonate; triethylamine; trifluoroacetic acid; In tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide; benzene;
DOI:10.1021/jo300974j