Technology Process of Isoquinoline, 1,2,3,4-tetrahydro-6,7-dimethoxy-1-((4-methoxyphenyl)methyl)-2-methyl-
There total 86 articles about Isoquinoline, 1,2,3,4-tetrahydro-6,7-dimethoxy-1-((4-methoxyphenyl)methyl)-2-methyl- which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
formaldehyd; 7,12-O,O'-dimethylcoclaurine;
In
methanol;
for 2h;
With
sodium tetrahydroborate;
In
methanol;
for 5h;
DOI:10.1071/ch00023
- Guidance literature:
-
6,7-dimethoxy-2-methyl-1,2,3,4-tetrahydroisoquinoline-1-carbonitrile;
With
potassium hexamethylsilazane;
In
tetrahydrofuran;
at 0 ℃;
for 0.166667h;
Inert atmosphere;
p-Methoxybenzyl bromide;
In
tetrahydrofuran;
at 0 - 20 ℃;
for 5h;
Inert atmosphere;
With
sodium cyanoborohydride; acetic acid;
In
tetrahydrofuran; ethanol;
at 20 ℃;
for 15h;
Inert atmosphere;
DOI:10.1021/acs.orglett.7b00652
- Guidance literature:
-
(R)-1-(4'-methoxybenzyl)-6,7-dimethoxy-1,2,3,4-tetrahydroisoquinoline; dimethyl dicarbonate;
In
dichloromethane;
at 20 ℃;
for 0.333333h;
With
lithium aluminium tetrahydride;
In
diethyl ether;
at 0 ℃;
for 0.333333h;
Further stages.;
DOI:10.1021/jo001397s
