60383-76-8

Basic information

• Product Name: (R)-1-(4'-methoxybenzyl)-6,7-dimethoxy-1,2,3,4-tetrahydroisoquinoline
• Synonyms: (R)-1-(4'-methoxybenzyl)-6,7-dimethoxy-1,2,3,4-tetrahydroisoquinoline
• CAS NO: 60383-76-8
• Molecular Weight: 313.397
• Mol File: 60383-76-8.mol
• Article Data: 7

Chemical Properties

• CAS DataBase Reference: (R)-1-(4'-methoxybenzyl)-6,7-dimethoxy-1,2,3,4-tetrahydroisoquinoline(CAS DataBase Reference)
• NIST Chemistry Reference: (R)-1-(4'-methoxybenzyl)-6,7-dimethoxy-1,2,3,4-tetrahydroisoquinoline(60383-76-8)
• EPA Substance Registry System: (R)-1-(4'-methoxybenzyl)-6,7-dimethoxy-1,2,3,4-tetrahydroisoquinoline(60383-76-8)

Safety Data

• Hazardous Substances Data: 60383-76-8(Hazardous Substances Data)

Upstream product

• 72527-29-8 6,7-dimethoxy-1-(4-methoxybenzyl)-3,4-dihydroisoquinoline 
• 41498-37-7 7,12-O,O'-dimethylcoclaurine 
• 321669-88-9 3-[(2'-bromo-4',5'-dimethoxyphenyl)ethyl]-2α-(p-methoxybenzyl)-4,4,7α-trimethyl-trans-octahydro-1,3-benzoxazine 
• 90841-59-1 2-(2-bromo-4,5-dimethoxyphenyl)acetaldehyde 
• 702-23-8 2-(4-Methoxyphenyl)ethanol 
• 55171-60-3 2-bromo-3,4-dimethoxybenzylaldehyde 
• 5703-26-4 4-Methoxyphenylacetaldehyde 
• 1210-57-7 6,7-dimethoxy-1,2,3,4-tetrahydroisoquinoline-1-carbonitrile 
• 14301-36-1 N-[2-(3,4-dimethoxyphenyl)ethyl]formamide 
• 3382-18-1 6,7-dimethoxy-3,4-dihydro-isoquinoline 
• 321669-63-0 2α-(2'-bromo-4',5'-dimethoxyphenylmethyl)-4,4,7α-trimethyl-trans-octahydro-1,3-benzoxazine 
• 321669-67-4 N-[(2'-bromo-4',5'-dimethoxyphenyl)ethyl]-8-aminomenthol 

Downstream Products

• 5701-00-8 (R)-O-methylarmepavine 

Relevant articles and documents

Synthesis of (-)-(S)-norlaudanosine, (+)-(R)-O,O-dimethylcoclaurine, and (+)-(R)-salsolidine by alkylation of an α-aminonitrile

A short asymmetric synthesis of 1-substituted 1,2,3,4- tetrahydroisoquinoline alkaloids by deprotonation of an unprotected α-aminonitrile and alkylation of the resulting carbanion followed by spontaneous elimination of HCN and asymmetric reduction is described. Wiley-VCH Verlag GmbH & Co. KGaA, 2007.

METHOD FOR RESOLVING ENANTIOMERS FROM RACEMIC MIXTURE HAVING CHIRAL CARBON IN ALPHA POSITION OF NITROGEN

Disclosed relates to a simplified method for resolving enantiomers by dissolving a racemic mixture having chiral carbon in α-position of nitrogen and an amino acid to prepare a diastereomeric salt, not using catalyses or enzymes, with enhancing the optical purity remarkably. Moreover, the present invention can prepare the enantiomers in large quantities without using expensive catalysts or without controlling the reaction conditions for the activity of enzymes applied.

METHOD FOR RESOLVING ENANTIOMERS FROM RACEMIC MIXTURE HAVING CHIRAL CARBON IN ALPHA POSITION OF NITROGEN

Disclosed relates to a simplified method for resolving enantiomers by dissolving a racemic mixture having chiral carbon in α-position of nitrogen and an amino acid to prepare a diastereomeric salt, not using catalyses or enzymes, with enhancing the optical purity remarkably. Moreover, the present invention can prepare the enantiomers in large quantities without using expensive catalysts or without controlling the reaction conditions for the activity of enzymes applied.