41498-37-7

Usage

Uses

Used in Agricultural Industry:
GS 389 is used as a pesticide and insecticide for protecting crops from pests and diseases. Its application helps in reducing crop damage and increasing agricultural productivity.
However, due to its potential toxicity to humans and animals, it is crucial to adhere to safety guidelines when handling GS 389. Additionally, its environmental impact, including harm to non-target species and persistence in the environment, necessitates responsible use and consideration of alternative pest control methods.

InChI:InChI=1/C19H23NO3/c1-21-15-6-4-13(5-7-15)10-17-16-12-19(23-3)18(22-2)11-14(16)8-9-20-17/h4-7,11-12,17,20H,8-10H2,1-3H3

Upstream product

• 72527-29-8 6,7-dimethoxy-1-(4-methoxybenzyl)-3,4-dihydroisoquinoline 
• 186581-53-3 diazomethane 
• 2033-08-1 coclaurine 
• 104-01-8 4-Methoxyphenylacetic acid 
• 4230-93-7 1,2-dimethoxy-4-(2-nitro-vinyl)-benzene 
• 4078-65-3 N-[2-(3,4-dimethoxy-phenyl)-ethyl]-2-(4-methoxy-phenyl)-acetamide 
• 101585-03-9 1-[(4-methoxyphenyl)methyl]-1,2,3,4-tetrahydroisoquinoline-6,7-diol 
• 20359-10-8 (6,7-dimethoxyisoquinolinyl)-(4'-methoxyphenyl)-methanone 
• 114105-51-0 (S)-(-)-[2-(3,4-dimethoxyphenyl)ethyl](1-phenylethyl)amine 
• 1421820-27-0 N-[2-(3,4-dimethoxyphenyl)ethyl]-N-[1-((1S)-phenyl)ethyl]-2-(4-methoxyphenyl)acetamide 
• 3382-18-1 6,7-dimethoxy-3,4-dihydro-isoquinoline 
• 2746-25-0 p-Methoxybenzyl bromide 
• 6834-42-0 3-methoxyphenylacetic acid chloride 
• 4693-91-8 4-methoxyphenyl-acetic chloride 

Downstream Products

• 1934-93-6 6,7-dimethoxy-1-(4-methoxybenzyl)-2-methyl-1,2,3,4-tetrahydroisoquinoline 
• 102759-47-7 polysignine 
• 308803-66-9 (E)-methyl N-[2-(4,5-dimethoxy-2-[2-(4-methoxyphenyl)ethenyl]phenyl)ethyl]-N-methylcarbamate 
• 308803-68-1 methyl N-[2-(4,5-dimethoxy-2-[2-(4-methoxyphenyl)ethyl]phenyl)ethyl]-N-methylcarbamate 
• 60383-76-8 (R)-1-(4'-methoxybenzyl)-6,7-dimethoxy-1,2,3,4-tetrahydroisoquinoline 
• 3611-33-4 O,O-Dimethylcoclaurine 
• 20359-10-8 (6,7-dimethoxyisoquinolinyl)-(4'-methoxyphenyl)-methanone 
• 1443828-60-1 ((6,7-dimethoxy-1-(3-methoxybenzyl)-3,4-dihydroisoquinolin-2(1H)-yl)(phenyl)methanone) 
• 1443828-58-7 ((6,7-dimethoxy-1-(4-methoxybenzyl)-3,4-dihydroisoquinolin-2(1H)-yl)(phenyl)methanone) 
• 1443828-59-8 ((3-chlorophenyl)(6,7-dimethoxy-1-(4-methoxybenzyl)-3,4-dihydroisoquinolin-2(1H)-yl)methanone) 
• 5843-65-2 higenamine 

Relevant academic research and scientific papers

Berbamine Analogs Exhibit Differential Protective Effects From Aminoglycoside-Induced Hair Cell Death

Hearing loss is the third most common chronic health condition in the United States and largely results from damage to sensory hair cells. Major causes of hair cell damage include aging, noise exposure, and medications such as aminoglycoside antibiotics.

Synthesis technology of higenamine and pharmaceutical salt of higenamine

The invention discloses a synthesis technology of higenamine and pharmaceutical salt of the higenamine, and belongs to the technical field of medicine synthesis. According to the synthesis technology,4-methoxyphenylacetic acid is used as a raw material, and through steps of reduction, oxidation, cyclization, deprotection and the like, the higenamine and the hydrochloride of the higenamine are obtained. Compared with existing technical routes, the synthesis technology has the few steps, and is simple to operate, the raw material is cheap, reaction conditions are mild, a reaction process is easy to control, the total yield and the purity are high, and the synthesis technology is environmentally friendly, safe and suitable for industrial production, and has large industrial prospects.

Tetrahydroisoquinoline derivative and application thereof

Provided are a tetrahydroisoquinoline derivative and an application thereof. The invention relates to a compound represented by the formula (V) and a preparation method and an application thereof in medicines. In particular, the invention relates to the d

Enantioselective Oxidative Aerobic Dealkylation of N-Ethyl Benzylisoquinolines by Employing the Berberine Bridge Enzyme

N-Dealkylation methods are well described for organic chemistry and the reaction is known in nature and drug metabolism; however, to our knowledge, enantioselective N-dealkylation has not been yet reported. In this study, exclusively the (S)-enantiomers o

Synthesis of (+)-O-methylthalibrine by employing a stereocontrolled Bischler-Napieralski reaction and an electrochemically generated diaryl ether

An efficient electrochemical four-step route was developed for the preparation of diaryl ether derivatives by using halogenation and dehalogenation processes in addition to electrochemical phenolic oxidation and reduction reactions. The synthesis of (+)-O

Synthesis of 8-oxoberbines and related benzolactams by Pd(OAc) 2-catalyzed direct aromatic carbonylation

A variety of alkoxy-substituted benzolactams with a berbine or yohimbane skeleton were prepared from 1-benzyl-1,2,3,4-tetrahydroisoquinolines or 1-benzyl-1,2,3,4-tetrahydro-β-carbolines by a phosphine-free Pd(II)-catalyzed direct aromatic carbonylation in a Pd(OAc)2-Cu(OAc) 2 catalytic system. The site selectivity was compared with that of the carbonylation with Pd(OAc)2 or Pd(OAc)2·2 PPh3, respectively.

Synthesis and structure activity relationship of tetrahydroisoquinoline- based potentiators of GluN2C and GluN2D containing N-Methyl-D-aspartate receptors

We describe here the synthesis and evaluation of a series of tetrahydroisoquinolines that show subunit-selective potentiation of NMDA receptors containing the GluN2C or GluN2D subunits. Bischler-Napieralski conditions were employed in the key step for the

Oxidation of 1-benzyldihydroisoquinolines or 1- benzyltetrahydroisoquinolines with dioxygen to 1-benzoylisoquinolines

An environmental-benign methodology to synthesize 1-benzoylisoquinolines from 1-benzyl-3, 4-dihydroisoquinolines or 1-benzyl-1,2,3,4- tetrahydroisoquinolines using dioxygen as an oxidant was developed. This methodology in combination with Bischler-Napieralski reaction leads to a facile synthesis of 1-benzoylisoquinolines from phenylacetic acids and phenylethanamines.

Synthesis of tetrahydroisoquinoline alkaloids via anodic cyanation as the key step

We report a new route to tetrahydroisoquinoline (THIQ) alkaloids involving the alkylation of α-aminonitrile 2 as a key step. The latter compound was prepared by anodic cyanation of the corresponding tertiary amine 1. Reductive decyanation of α-aminonitriles 6a-c proceeded diastereoselectively (up to 95% de) to deliver the C1-substituted alkaloids precursors 9a-c. The syntheses of (±)-carnegine, (±)-norlaudanosine, and (±)-O,O- dimethylcoclaurine have been achieved.

A new benzylisoquinoline alkaloid from Argemone mexicana

A new benzylisoquinoline alkaloid, argemexirine, together with two known protoberberine alkaloids, dl-tetrahydrocoptisine and dihydrocoptisine, have been isolated from the methanolic extract of the whole plant of Argemone mexicana L. The compounds were identified by spectral and chemical evidence. This is the first report of these alkaloids in this plant species.