Technology Process of 1,1-dibromo-2-(3-ethoxy-4-methoxyphenyl)ethene
There total 1 articles about 1,1-dibromo-2-(3-ethoxy-4-methoxyphenyl)ethene which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
triphenylphosphine;
In
dichloromethane;
for 0.666667h;
cooling;
DOI:10.1002/ejoc.200600372
- Guidance literature:
-
With
n-butyllithium;
In
tetrahydrofuran; pentane;
at -78 - 23 ℃;
for 3h;
DOI:10.1002/ejoc.200600372
- Guidance literature:
-
Multi-step reaction with 8 steps
1.1: n-butyllithium / tetrahydrofuran / 3 h / -78 - 20 °C
1.2: 20 °C
2.1: hydrogen bromide; acetic acid / 0.25 h
3.1: tert.-butyl lithium / tetrahydrofuran / 1.5 h / -78 °C
3.2: 1.5 h / -78 - 20 °C
4.1: manganese(IV) oxide / dichloromethane / 0.58 - 1 h / 20 °C
5.1: sodium sulfide / tetrahydrofuran; water / 3 h / 55 °C
6.1: dihydrogen peroxide; acetic acid / 2 h / 80 °C
7.1: hydrogen; toluene-4-sulfonic acid / platinum on carbon / methanol / 60 °C / 75.01 Torr
7.2: pH ~ 6.0
8.1: hydrogenchloride; hydrogen / palladium on activated charcoal / methanol; water / 60 °C / 75.01 Torr
With
hydrogenchloride; manganese(IV) oxide; sodium sulfide; n-butyllithium; hydrogen bromide; hydrogen; dihydrogen peroxide; tert.-butyl lithium; toluene-4-sulfonic acid; acetic acid;
platinum on carbon; palladium on activated charcoal;
In
tetrahydrofuran; methanol; dichloromethane; water;
