4-chlorobenzyl 4-[2-(1H-benzotriazol-5-ylcarbamoyl)acetylamino]piperidine-1-carboxylate

Base Information

Chemical Name:4-chlorobenzyl 4-[2-(1H-benzotriazol-5-ylcarbamoyl)acetylamino]piperidine-1-carboxylate
CAS No.:1246639-74-6
Molecular Formula:C₂₂H₂₃ClN₆O₄
Molecular Weight:470.915
Hs Code.:

Synonyms:4-chlorobenzyl 4-[2-(1H-benzotriazol-5-ylcarbamoyl)acetylamino]piperidine-1-carboxylate

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Chemical Property of 4-chlorobenzyl 4-[2-(1H-benzotriazol-5-ylcarbamoyl)acetylamino]piperidine-1-carboxylate

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Technology Process of 4-chlorobenzyl 4-[2-(1H-benzotriazol-5-ylcarbamoyl)acetylamino]piperidine-1-carboxylate

There total 4 articles about 4-chlorobenzyl 4-[2-(1H-benzotriazol-5-ylcarbamoyl)acetylamino]piperidine-1-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 22.0%

: 3325-11-9
5-aminobenzotriazole

: 1246640-07-2
C₁₆H₁₉ClN₂O₅

: 1246639-74-6
4-chlorobenzyl 4-[2-(1H-benzotriazol-5-ylcarbamoyl)acetylamino]piperidine-1-carboxylate

Guidance literature:: With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In N,N-dimethyl-formamide; at 20 ℃; for 16h;

Reference yield:

: 847458-69-9
C₁₇H₂₄N₂O₃

: 1246639-74-6
4-chlorobenzyl 4-[2-(1H-benzotriazol-5-ylcarbamoyl)acetylamino]piperidine-1-carboxylate

Guidance literature:: Multi-step reaction with 4 steps

1.1: hydrogen / palladium on activated charcoal / tetrahydrofuran; acetic acid

2.1: N,N-dimethyl-formamide / 2 h / 20 °C

2.2: 16 h / 20 °C

3.1: sodium hydroxide; water / ethanol / 16 h / 20 °C

4.1: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol / N,N-dimethyl-formamide / 16 h / 20 °C

With water; hydrogen; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; sodium hydroxide; palladium on activated charcoal; In tetrahydrofuran; ethanol; acetic acid; N,N-dimethyl-formamide;

Reference yield:

: 50541-93-0
4-amino-1-benzylpiperidine

: 1246639-74-6
4-chlorobenzyl 4-[2-(1H-benzotriazol-5-ylcarbamoyl)acetylamino]piperidine-1-carboxylate

Guidance literature:: Multi-step reaction with 5 steps

1.1: triethylamine / dichloromethane / 20 °C / Cooling

2.1: hydrogen / palladium on activated charcoal / tetrahydrofuran; acetic acid

3.1: N,N-dimethyl-formamide / 2 h / 20 °C

3.2: 16 h / 20 °C

4.1: sodium hydroxide; water / ethanol / 16 h / 20 °C

5.1: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol / N,N-dimethyl-formamide / 16 h / 20 °C

With water; hydrogen; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; sodium hydroxide; palladium on activated charcoal; In tetrahydrofuran; ethanol; dichloromethane; acetic acid; N,N-dimethyl-formamide;