Technology Process of 4-(2,6-diethyl-4-methylphenyl)-2-methyl-5-methylsulfinyl-6-trifluoromethyl-2,3-dihydro-3-pyridazinone
There total 13 articles about 4-(2,6-diethyl-4-methylphenyl)-2-methyl-5-methylsulfinyl-6-trifluoromethyl-2,3-dihydro-3-pyridazinone which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
With
sodium hydrogencarbonate; 3-chloro-benzenecarboperoxoic acid;
In
chloroform;
at 20 ℃;
for 3h;
- Guidance literature:
-
Multi-step reaction with 8 steps
1.1: magnesium; ethylene dibromide / toluene; tetrahydrofuran / 52 h / 40 - 50 °C / Inert atmosphere
1.2: 2 h / 0 - 5 °C / Inert atmosphere
2.1: hydrazine hydrate / methanol / 4.08 h / 1 - 2 °C
3.1: toluene / 2 h / 50 °C / 100 Torr / Inert atmosphere
4.1: potassium carbonate / toluene / 24 h / 5 °C
5.1: hydrogen / 5%-palladium/activated carbon / 1,2-dimethoxyethane / 8 h / 20 °C
6.1: toluene-4-sulfonic acid / toluene / 20 °C / Reflux
7.1: potassium tert-butylate / toluene; tetrahydrofuran / 4.13 h / 20 °C
8.1: sodium hydrogencarbonate; 3-chloro-benzenecarboperoxoic acid / chloroform / 3 h / 20 °C
With
potassium tert-butylate; hydrogen; sodium hydrogencarbonate; potassium carbonate; toluene-4-sulfonic acid; hydrazine hydrate; magnesium; ethylene dibromide; 3-chloro-benzenecarboperoxoic acid;
5%-palladium/activated carbon;
In
tetrahydrofuran; methanol; 1,2-dimethoxyethane; chloroform; toluene;
- Guidance literature:
-
Multi-step reaction with 7 steps
1: hydrazine hydrate / methanol / 4.08 h / 1 - 2 °C
2: toluene / 2 h / 50 °C / 100 Torr / Inert atmosphere
3: potassium carbonate / toluene / 24 h / 5 °C
4: hydrogen / 5%-palladium/activated carbon / 1,2-dimethoxyethane / 8 h / 20 °C
5: toluene-4-sulfonic acid / toluene / 20 °C / Reflux
6: potassium tert-butylate / toluene; tetrahydrofuran / 4.13 h / 20 °C
7: sodium hydrogencarbonate; 3-chloro-benzenecarboperoxoic acid / chloroform / 3 h / 20 °C
With
potassium tert-butylate; hydrogen; sodium hydrogencarbonate; potassium carbonate; toluene-4-sulfonic acid; hydrazine hydrate; 3-chloro-benzenecarboperoxoic acid;
5%-palladium/activated carbon;
In
tetrahydrofuran; methanol; 1,2-dimethoxyethane; chloroform; toluene;
