4-(2,6-diethyl-4-methylphenyl)-2-methyl-5-methylsulfanyl-6-trifluoromethyl-2,3-dihydro-3-pyridazinone

Base Information

Chemical Name:4-(2,6-diethyl-4-methylphenyl)-2-methyl-5-methylsulfanyl-6-trifluoromethyl-2,3-dihydro-3-pyridazinone
CAS No.:1363807-58-2
Molecular Formula:C₁₈H₂₁F₃N₂OS
Molecular Weight:370.439
Hs Code.:

Synonyms:4-(2,6-diethyl-4-methylphenyl)-2-methyl-5-methylsulfanyl-6-trifluoromethyl-2,3-dihydro-3-pyridazinone

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Chemical Property of 4-(2,6-diethyl-4-methylphenyl)-2-methyl-5-methylsulfanyl-6-trifluoromethyl-2,3-dihydro-3-pyridazinone

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Technology Process of 4-(2,6-diethyl-4-methylphenyl)-2-methyl-5-methylsulfanyl-6-trifluoromethyl-2,3-dihydro-3-pyridazinone

There total 12 articles about 4-(2,6-diethyl-4-methylphenyl)-2-methyl-5-methylsulfanyl-6-trifluoromethyl-2,3-dihydro-3-pyridazinone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1363807-53-7
1-[2-(2,6-diethyl-4-methylphenyl)-2-oxoacetyl]-2-(1,1,1-trifluoro-3-methylsulfanyl-2-propylidene)-1-methylhydrazine

: 1363807-58-2
4-(2,6-diethyl-4-methylphenyl)-2-methyl-5-methylsulfanyl-6-trifluoromethyl-2,3-dihydro-3-pyridazinone

Guidance literature:: With potassium tert-butylate; In tetrahydrofuran; toluene; at 20 ℃; for 4.13333h;

Reference yield:

: 314084-61-2
1-bromo-2,6-diethyl-4-methylbenzene

: 1363807-58-2
4-(2,6-diethyl-4-methylphenyl)-2-methyl-5-methylsulfanyl-6-trifluoromethyl-2,3-dihydro-3-pyridazinone

Guidance literature:: Multi-step reaction with 7 steps

1.1: magnesium; ethylene dibromide / toluene; tetrahydrofuran / 52 h / 40 - 50 °C / Inert atmosphere

1.2: 2 h / 0 - 5 °C / Inert atmosphere

2.1: sodium hydroxide; water / tetrahydrofuran / 3 h / 10 - 20 °C

3.1: thionyl chloride / N,N-dimethyl-formamide / toluene / 2 h / 50 °C / Inert atmosphere

4.1: triethylamine / acetonitrile / 1.5 h / 1 - 20 °C / Inert atmosphere

5.1: hydrogenchloride / water; tetrahydrofuran / 1.08 h / 20 °C / Inert atmosphere

6.1: toluene-4-sulfonic acid / toluene / 20 °C / Reflux

7.1: potassium tert-butylate / toluene; tetrahydrofuran / 4.13 h / 20 °C

With hydrogenchloride; thionyl chloride; potassium tert-butylate; water; toluene-4-sulfonic acid; magnesium; ethylene dibromide; triethylamine; sodium hydroxide; N,N-dimethyl-formamide; In tetrahydrofuran; water; toluene; acetonitrile;

Reference yield:

: 1363806-98-7
ethyl 2-(2,6-diethyl-4-methylphenyl)-2-oxoacetate

: 1363807-58-2
4-(2,6-diethyl-4-methylphenyl)-2-methyl-5-methylsulfanyl-6-trifluoromethyl-2,3-dihydro-3-pyridazinone

Guidance literature:: Multi-step reaction with 6 steps

1: hydrazine hydrate / methanol / 4.08 h / 1 - 2 °C

2: methanol / 1.5 h / 20 °C

3: potassium carbonate / N,N-dimethyl-formamide / 2.5 h / 20 °C

4: hydroxylamine / water; methanol / 17 h / 50 - 60 °C

5: toluene-4-sulfonic acid / toluene / 20 °C / Reflux

6: potassium tert-butylate / toluene; tetrahydrofuran / 4.13 h / 20 °C

With potassium tert-butylate; hydroxylamine; potassium carbonate; toluene-4-sulfonic acid; hydrazine hydrate; In tetrahydrofuran; methanol; water; N,N-dimethyl-formamide; toluene;