(4S,5S)-2-[N-(2,2-dimethyl-4-phenyl-1,3-dioxan-5-yl)(methyl)amino]-2-(4-methoxyphenyl)acetonitrile

Base Information

• Chemical Name: (4S,5S)-2-[N-(2,2-dimethyl-4-phenyl-1,3-dioxan-5-yl)(methyl)amino]-2-(4-methoxyphenyl)acetonitrile
• CAS No.: 204439-58-7
• Molecular Formula: C₂₂H₂₆N₂O₃
• Molecular Weight: 366.46
• Mol file: 204439-58-7.mol

Synonyms:(4S,5S)-2-[N-(2,2-dimethyl-4-phenyl-1,3-dioxan-5-yl)(methyl)amino]-2-(4-methoxyphenyl)acetonitrile

Chemical Property of (4S,5S)-2-[N-(2,2-dimethyl-4-phenyl-1,3-dioxan-5-yl)(methyl)amino]-2-(4-methoxyphenyl)acetonitrile

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (4S,5S)-2-[N-(2,2-dimethyl-4-phenyl-1,3-dioxan-5-yl)(methyl)amino]-2-(4-methoxyphenyl)acetonitrile

There total 2 articles about (4S,5S)-2-[N-(2,2-dimethyl-4-phenyl-1,3-dioxan-5-yl)(methyl)amino]-2-(4-methoxyphenyl)acetonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.0%

(4S,5S)-(+)-2,2-Dimethyl-5-methylamino-4-phenyl-1,3-dioxan (124686-47-1) + potassium cyanide (151-50-8) + 4-methoxy-benzaldehyde (123-11-5) → (4S,5S)-2-[N-(2,2-dimethyl-4-phenyl-1,3-dioxan-5-yl)(methyl)amino]-2-(4-methoxyphenyl)acetonitrile (204439-58-7)

Guidance literature:

With hydrogenchloride; In methanol; water; pH 5-7, 0 deg C, then room t.;

DOI:10.1055/s-1995-3968

Reference yield: 52.0%

potassium cyanide + (4S,5S)-(+)-2,2-Dimethyl-5-methylamino-4-phenyl-1,3-dioxan (124686-47-1) + 4-methoxy-benzaldehyde (123-11-5) → (4S,5S)-2-[N-(2,2-dimethyl-4-phenyl-1,3-dioxan-5-yl)(methyl)amino]-2-(4-methoxyphenyl)acetonitrile (204439-58-7)

Guidance literature:

With hydrogenchloride; In methanol; water;

DOI:10.1021/jo8017318

Reference yield: 95.0%

2-buten-4-olide (497-23-4) + (4S,5S)-2-[N-(2,2-dimethyl-4-phenyl-1,3-dioxan-5-yl)(methyl)amino]-2-(4-methoxyphenyl)acetonitrile (204439-58-7) + prenyl bromide (870-63-3) → (S)-[((4S,5S)-2,2-Dimethyl-4-phenyl-[1,3]dioxan-5-yl)-methyl-amino]-(4-methoxy-phenyl)-[(3R,4S)-4-(3-methyl-but-2-enyl)-5-oxo-tetrahydro-furan-3-yl]-acetonitrile

Guidance literature:

With n-butyllithium; In tetrahydrofuran; N,N,N,N,N,N-hexamethylphosphoric triamide; hexane; at -30 ℃; for 4h;

upstream raw materials:

(4S,5S)-(+)-2,2-Dimethyl-5-methylamino-4-phenyl-1,3-dioxan

potassium cyanide

4-methoxy-benzaldehyde

Downstream raw materials:

(R)-[((4S,5S)-2,2-Dimethyl-4-phenyl-[1,3]dioxan-5-yl)-methyl-amino]-(4-methoxy-phenyl)-[(1R,2S)-2-(3-methyl-but-2-enyl)-3-oxo-cyclohexyl]-acetonitrile