1-(benzylmethylcarbamoyl)cyclopropanecarboxylic acid ethyl ester

Base Information

• Chemical Name: 1-(benzylmethylcarbamoyl)cyclopropanecarboxylic acid ethyl ester
• CAS No.: 299204-32-3
• Molecular Formula: C₁₅H₁₉NO₃
• Molecular Weight: 261.321
• Mol file: 299204-32-3.mol

Synonyms:1-(benzylmethylcarbamoyl)cyclopropanecarboxylic acid ethyl ester

Chemical Property of 1-(benzylmethylcarbamoyl)cyclopropanecarboxylic acid ethyl ester

Chemical Property:

Purity/Quality:

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MSDS Files:

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Technology Process of 1-(benzylmethylcarbamoyl)cyclopropanecarboxylic acid ethyl ester

There total 2 articles about 1-(benzylmethylcarbamoyl)cyclopropanecarboxylic acid ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

1,1-cyclopropanedicarboxylic acid monoethyl ester (3697-66-3) → 1-(benzylmethylcarbamoyl)cyclopropanecarboxylic acid ethyl ester (299204-32-3)

Guidance literature:

Multi-step reaction with 2 steps

1: oxalyl chloride; DMF / CH₂Cl₂ / 3 h / 20 °C

2: CH₂Cl₂ / 24 h / 20 °C

With oxalyl dichloride; N,N-dimethyl-formamide; In dichloromethane; 1: Chlorination / 2: Acylation;

DOI:10.1021/ja001088j

Reference yield:

ethyl 1-chlorocarbonylcyclopropanecarboxylate (3697-67-4) + benzyl-methyl-amine (103-67-3) → 1-(benzylmethylcarbamoyl)cyclopropanecarboxylic acid ethyl ester (299204-32-3)

Guidance literature:

In dichloromethane; at 20 ℃; for 24h;

DOI:10.1021/ja001088j

Reference yield:

1-(benzylmethylcarbamoyl)cyclopropanecarboxylic acid ethyl ester (299204-32-3) → 1-(benzylmethylcarbamoyl)cyclopropanecarboxylic acid (299204-33-4)

Guidance literature:

With potassium hydroxide; In ethanol; at 20 ℃; for 24h;

DOI:10.1021/ja001088j

upstream raw materials:

ethyl 1-chlorocarbonylcyclopropanecarboxylate

benzyl-methyl-amine

1,1-cyclopropanedicarboxylic acid monoethyl ester

Downstream raw materials:

1-(benzylmethylcarbamoyl)cyclopropanecarboxylic acid

3-[(1-benzylmethylcarbamoyl)cyclopropyl]-2-diazo-3-oxopropionic acid ethyl ester

3-[(1-benzylmethylcarbamoyl)cyclopropyl]-3-oxopropionic acid ethyl ester