Technology Process of Ethyl 1-[[methyl(phenylmethyl)amino]carbonyl]-beta-oxocyclopropanepropanoate
There total 5 articles about Ethyl 1-[[methyl(phenylmethyl)amino]carbonyl]-beta-oxocyclopropanepropanoate which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
hydrogen ethyl malonate;
With
isopropylmagnesium chloride;
In
tetrahydrofuran;
at 0 ℃;
for 0.5h;
1-(benzyl-methyl-carbamoyl)-cyclopropanecarbonyl chloride;
In
tetrahydrofuran;
at 0 ℃;
for 1h;
Further stages.;
DOI:10.1021/ja001088j
- Guidance literature:
-
Multi-step reaction with 4 steps
1.1: CH2Cl2 / 24 h / 20 °C
2.1: KOH / ethanol / 24 h / 20 °C
3.1: oxalyl chloride; DMF / CH2Cl2 / 2 h / 20 °C
4.1: i-PrMgCl / tetrahydrofuran / 0.5 h / 0 °C
4.2: 42 percent / tetrahydrofuran / 1 h / 0 °C
With
potassium hydroxide; oxalyl dichloride; isopropylmagnesium chloride; N,N-dimethyl-formamide;
In
tetrahydrofuran; ethanol; dichloromethane;
1.1: Acylation / 2.1: Hydrolysis / 3.1: Chlorination / 4.1: Metallation / 4.2: Acylation;
DOI:10.1021/ja001088j
- Guidance literature:
-
Multi-step reaction with 5 steps
1.1: oxalyl chloride; DMF / CH2Cl2 / 3 h / 20 °C
2.1: CH2Cl2 / 24 h / 20 °C
3.1: KOH / ethanol / 24 h / 20 °C
4.1: oxalyl chloride; DMF / CH2Cl2 / 2 h / 20 °C
5.1: i-PrMgCl / tetrahydrofuran / 0.5 h / 0 °C
5.2: 42 percent / tetrahydrofuran / 1 h / 0 °C
With
potassium hydroxide; oxalyl dichloride; isopropylmagnesium chloride; N,N-dimethyl-formamide;
In
tetrahydrofuran; ethanol; dichloromethane;
1.1: Chlorination / 2.1: Acylation / 3.1: Hydrolysis / 4.1: Chlorination / 5.1: Metallation / 5.2: Acylation;
DOI:10.1021/ja001088j
