(R)-4-(2-carboxy-5-phenylthiophen-3-yl)-3-cyclohexyl-5-oxopiperazine-1-carboxylic acid tert-butyl ester

Base Information

Chemical Name:(R)-4-(2-carboxy-5-phenylthiophen-3-yl)-3-cyclohexyl-5-oxopiperazine-1-carboxylic acid tert-butyl ester
CAS No.:1356453-54-7
Molecular Formula:C₂₆H₃₂N₂O₅S
Molecular Weight:484.616
Hs Code.:

Synonyms:(R)-4-(2-carboxy-5-phenylthiophen-3-yl)-3-cyclohexyl-5-oxopiperazine-1-carboxylic acid tert-butyl ester

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Chemical Property of (R)-4-(2-carboxy-5-phenylthiophen-3-yl)-3-cyclohexyl-5-oxopiperazine-1-carboxylic acid tert-butyl ester

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Technology Process of (R)-4-(2-carboxy-5-phenylthiophen-3-yl)-3-cyclohexyl-5-oxopiperazine-1-carboxylic acid tert-butyl ester

There total 9 articles about (R)-4-(2-carboxy-5-phenylthiophen-3-yl)-3-cyclohexyl-5-oxopiperazine-1-carboxylic acid tert-butyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

: 1356457-08-3
(R)-3-cyclohexyl-4-(2-methoxycarbonyl-5-phenylthiophen-3-yl)-5-oxopiperazine-1-carboxylic acid tert-butyl ester

: 1356453-54-7
(R)-4-(2-carboxy-5-phenylthiophen-3-yl)-3-cyclohexyl-5-oxopiperazine-1-carboxylic acid tert-butyl ester

Guidance literature:: (R)-3-cyclohexyl-4-(2-methoxycarbonyl-5-phenylthiophen-3-yl)-5-oxopiperazine-1-carboxylic acid tert-butyl ester; With lithium hydroxide monohydrate; water; In tetrahydrofuran; methanol; at 55 ℃; for 1h;

With hydrogenchloride; In tetrahydrofuran; methanol; water; pH=5;

Reference yield:

: 1356457-06-1
(R)-2-(2-(benzyloxycarbonylamino)-2-cyclohexylethylamino)acetic acid methyl ester

: 1356453-54-7
(R)-4-(2-carboxy-5-phenylthiophen-3-yl)-3-cyclohexyl-5-oxopiperazine-1-carboxylic acid tert-butyl ester

Guidance literature:: Multi-step reaction with 4 steps

1.1: hydrogen / palladium 10% on activated carbon / methanol / 18 h / 760.05 Torr / Inert atmosphere

2.1: dichloromethane / 1 h / 20 °C

3.1: potassium carbonate; copper(l) iodide / 1,4-dioxane / 72 h / 110 °C / Sealed; Inert atmosphere

4.1: water; lithium hydroxide monohydrate / tetrahydrofuran; methanol / 1 h / 55 °C

4.2: pH 5

With copper(l) iodide; lithium hydroxide monohydrate; water; hydrogen; potassium carbonate; palladium 10% on activated carbon; In tetrahydrofuran; 1,4-dioxane; methanol; dichloromethane;

Reference yield:

: 876761-30-7
(R)-1-cyclohexyl-2-(methoxy(methyl)amino)-2-oxoethylcarbamic acid benzyl ester

: 1356453-54-7
(R)-4-(2-carboxy-5-phenylthiophen-3-yl)-3-cyclohexyl-5-oxopiperazine-1-carboxylic acid tert-butyl ester

Guidance literature:: Multi-step reaction with 6 steps

1.1: lithium aluminium tetrahydride / tetrahydrofuran / -20 - 0 °C

1.2: pH 5

2.1: N-ethyl-N,N-diisopropylamine / dichloromethane / 0 °C

2.2: 3 h / 20 °C

2.3: pH 8

3.1: hydrogen / palladium 10% on activated carbon / methanol / 18 h / 760.05 Torr / Inert atmosphere

4.1: dichloromethane / 1 h / 20 °C

5.1: potassium carbonate; copper(l) iodide / 1,4-dioxane / 72 h / 110 °C / Sealed; Inert atmosphere

6.1: water; lithium hydroxide monohydrate / tetrahydrofuran; methanol / 1 h / 55 °C

6.2: pH 5

With copper(l) iodide; lithium aluminium tetrahydride; lithium hydroxide monohydrate; water; hydrogen; potassium carbonate; N-ethyl-N,N-diisopropylamine; palladium 10% on activated carbon; In tetrahydrofuran; 1,4-dioxane; methanol; dichloromethane;