(R)-2-(2-(benzyloxycarbonylamino)-2-cyclohexylethylamino)acetic acid methyl ester

Base Information

Chemical Name:(R)-2-(2-(benzyloxycarbonylamino)-2-cyclohexylethylamino)acetic acid methyl ester
CAS No.:1356457-06-1
Molecular Formula:C₁₉H₂₈N₂O₄
Molecular Weight:348.442
Hs Code.:

Synonyms:(R)-2-(2-(benzyloxycarbonylamino)-2-cyclohexylethylamino)acetic acid methyl ester

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Chemical Property of (R)-2-(2-(benzyloxycarbonylamino)-2-cyclohexylethylamino)acetic acid methyl ester

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Technology Process of (R)-2-(2-(benzyloxycarbonylamino)-2-cyclohexylethylamino)acetic acid methyl ester

There total 3 articles about (R)-2-(2-(benzyloxycarbonylamino)-2-cyclohexylethylamino)acetic acid methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 876761-31-8
((R)-1-cyclohexyl-2-oxoethyl)carbamic acid benzyl ester

: 5680-79-5,883886-67-7
glycine ethyl ester hydrochloride

: 1356457-06-1
(R)-2-(2-(benzyloxycarbonylamino)-2-cyclohexylethylamino)acetic acid methyl ester

Guidance literature:: ((R)-1-cyclohexyl-2-oxoethyl)carbamic acid benzyl ester; glycine ethyl ester hydrochloride; With N-ethyl-N,N-diisopropylamine; In dichloromethane; at 0 ℃;

With sodium tris(acetoxy)borohydride; In dichloromethane; at 20 ℃; for 3h;

With sodium hydrogencarbonate; In dichloromethane; water; pH=8;

Reference yield:

: 69901-85-5
(R)-N-benzyloxycarbonylcyclohexylglicine

: 1356457-06-1
(R)-2-(2-(benzyloxycarbonylamino)-2-cyclohexylethylamino)acetic acid methyl ester

Guidance literature:: Multi-step reaction with 3 steps

1.1: HATU / N,N-dimethyl-formamide / -10 °C

1.2: -10 - 0 °C

2.1: lithium aluminium tetrahydride / tetrahydrofuran / -20 - 0 °C

2.2: pH 5

3.1: N-ethyl-N,N-diisopropylamine / dichloromethane / 0 °C

3.2: 3 h / 20 °C

3.3: pH 8

With lithium aluminium tetrahydride; N-ethyl-N,N-diisopropylamine; HATU; In tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide;

Reference yield:

: 876761-30-7
(R)-1-cyclohexyl-2-(methoxy(methyl)amino)-2-oxoethylcarbamic acid benzyl ester

: 1356457-06-1
(R)-2-(2-(benzyloxycarbonylamino)-2-cyclohexylethylamino)acetic acid methyl ester

Guidance literature:: Multi-step reaction with 2 steps

1.1: lithium aluminium tetrahydride / tetrahydrofuran / -20 - 0 °C

1.2: pH 5

2.1: N-ethyl-N,N-diisopropylamine / dichloromethane / 0 °C

2.2: 3 h / 20 °C

2.3: pH 8

With lithium aluminium tetrahydride; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; dichloromethane;