3-((R)-2-cyclohexyl-6-oxopiperazin-1-yl)-5-phenylthiophene-2-carboxylic acid hydrochloride

Base Information

Chemical Name:3-((R)-2-cyclohexyl-6-oxopiperazin-1-yl)-5-phenylthiophene-2-carboxylic acid hydrochloride
CAS No.:1356457-10-7
Molecular Formula:C₂₁H₂₄N₂O₃S*ClH
Molecular Weight:420.96
Hs Code.:

Synonyms:3-((R)-2-cyclohexyl-6-oxopiperazin-1-yl)-5-phenylthiophene-2-carboxylic acid hydrochloride

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Chemical Property of 3-((R)-2-cyclohexyl-6-oxopiperazin-1-yl)-5-phenylthiophene-2-carboxylic acid hydrochloride

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Technology Process of 3-((R)-2-cyclohexyl-6-oxopiperazin-1-yl)-5-phenylthiophene-2-carboxylic acid hydrochloride

There total 10 articles about 3-((R)-2-cyclohexyl-6-oxopiperazin-1-yl)-5-phenylthiophene-2-carboxylic acid hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

: 1356453-54-7
(R)-4-(2-carboxy-5-phenylthiophen-3-yl)-3-cyclohexyl-5-oxopiperazine-1-carboxylic acid tert-butyl ester

: 1356457-10-7
3-((R)-2-cyclohexyl-6-oxopiperazin-1-yl)-5-phenylthiophene-2-carboxylic acid hydrochloride

Guidance literature:: With hydrogenchloride; In 1,4-dioxane; at 20 ℃; for 2h;

Reference yield:

: 69901-85-5
(R)-N-benzyloxycarbonylcyclohexylglicine

: 1356457-10-7
3-((R)-2-cyclohexyl-6-oxopiperazin-1-yl)-5-phenylthiophene-2-carboxylic acid hydrochloride

Guidance literature:: Multi-step reaction with 8 steps

1.1: HATU / N,N-dimethyl-formamide / -10 °C

1.2: -10 - 0 °C

2.1: lithium aluminium tetrahydride / tetrahydrofuran / -20 - 0 °C

2.2: pH 5

3.1: N-ethyl-N,N-diisopropylamine / dichloromethane / 0 °C

3.2: 3 h / 20 °C

3.3: pH 8

4.1: hydrogen / palladium 10% on activated carbon / methanol / 18 h / 760.05 Torr / Inert atmosphere

5.1: dichloromethane / 1 h / 20 °C

6.1: potassium carbonate; copper(l) iodide / 1,4-dioxane / 72 h / 110 °C / Sealed; Inert atmosphere

7.1: water; lithium hydroxide monohydrate / tetrahydrofuran; methanol / 1 h / 55 °C

7.2: pH 5

8.1: hydrogenchloride / 1,4-dioxane / 2 h / 20 °C

With hydrogenchloride; copper(l) iodide; lithium aluminium tetrahydride; lithium hydroxide monohydrate; water; hydrogen; potassium carbonate; N-ethyl-N,N-diisopropylamine; HATU; palladium 10% on activated carbon; In tetrahydrofuran; 1,4-dioxane; methanol; dichloromethane; N,N-dimethyl-formamide;

Reference yield:

: 1356457-06-1
(R)-2-(2-(benzyloxycarbonylamino)-2-cyclohexylethylamino)acetic acid methyl ester

: 1356457-10-7
3-((R)-2-cyclohexyl-6-oxopiperazin-1-yl)-5-phenylthiophene-2-carboxylic acid hydrochloride

Guidance literature:: Multi-step reaction with 5 steps

1.1: hydrogen / palladium 10% on activated carbon / methanol / 18 h / 760.05 Torr / Inert atmosphere

2.1: dichloromethane / 1 h / 20 °C

3.1: potassium carbonate; copper(l) iodide / 1,4-dioxane / 72 h / 110 °C / Sealed; Inert atmosphere

4.1: water; lithium hydroxide monohydrate / tetrahydrofuran; methanol / 1 h / 55 °C

4.2: pH 5

5.1: hydrogenchloride / 1,4-dioxane / 2 h / 20 °C

With hydrogenchloride; copper(l) iodide; lithium hydroxide monohydrate; water; hydrogen; potassium carbonate; palladium 10% on activated carbon; In tetrahydrofuran; 1,4-dioxane; methanol; dichloromethane;