C₂₉H₂₆N₄O₈

Base Information

• Chemical Name: C₂₉H₂₆N₄O₈
• CAS No.: 1054653-88-1
• Molecular Formula: C₂₉H₂₆N₄O₈
• Molecular Weight: 558.547
• Mol file: 1054653-88-1.mol

Synonyms:C₂₉H₂₆N₄O₈

Chemical Property of C₂₉H₂₆N₄O₈

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of C₂₉H₂₆N₄O₈

There total 8 articles about C₂₉H₂₆N₄O₈ which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

4-aminopyrido[2,3-d]pyrimidin-5(8H)-one (306960-30-5) + 1,3-di-O-acetyl-2,5-di-O-benzoyl-3-C-methyl-D-ribofuranose (306960-21-4) → C29H26N4O8 + C29H26N4O8 (1054653-88-1)

Guidance literature:

4-aminopyrido[2,3-d]pyrimidin-5(8H)-one; With N,O-bis-(trimethylsilyl)-acetamide; In 1,2-dichloro-ethane; at 75 ℃; for 2h;

1,3-di-O-acetyl-2,5-di-O-benzoyl-3-C-methyl-D-ribofuranose; With trimethylsilyl trifluoromethanesulfonate; In 1,2-dichloro-ethane; for 72h; Further stages.; Heating;

DOI:10.1021/jm000073t

Reference yield:

((3aR,5R,6R,6aR)-6-hydroxy-2,2,6-trimethyltetrahydrofuro[2,3-d][1,3]dioxol-5-yl)methyl benzoate (16831-81-5) → C29H26N4O8 (1054653-88-1)

Guidance literature:

Multi-step reaction with 5 steps

1.1: pyridine / 72 h / 75 °C

2.1: TFA; H₂O / 2.5 h / -10 - 0 °C

3.1: pyridine / 20 °C

4.1: DMAP; Et₃N / CH₂Cl₂ / 3 h / 20 °C

5.1: N,O-bis(trimethylsilyl)acetamide / 1,2-dichloro-ethane / 2 h / 75 °C

5.2: trimethylsilyl triflate / 1,2-dichloro-ethane / 72 h / Heating

With pyridine; dmap; N,O-bis-(trimethylsilyl)-acetamide; water; triethylamine; trifluoroacetic acid; In dichloromethane; 1,2-dichloro-ethane; 5.2: Vorbrueggen reaction;

DOI:10.1021/jm000073t

Reference yield:

5-O-benzoyl-1,2-O-isopropylidene-α-D-ribofuranos-3-ulose (6698-46-0) → C29H26N4O8 (1054653-88-1)

Guidance literature:

Multi-step reaction with 6 steps

1.1: tetrahydrofuran; diethyl ether / 7 h / 0 °C

2.1: pyridine / 72 h / 75 °C

3.1: TFA; H₂O / 2.5 h / -10 - 0 °C

4.1: pyridine / 20 °C

5.1: DMAP; Et₃N / CH₂Cl₂ / 3 h / 20 °C

6.1: N,O-bis(trimethylsilyl)acetamide / 1,2-dichloro-ethane / 2 h / 75 °C

6.2: trimethylsilyl triflate / 1,2-dichloro-ethane / 72 h / Heating

With pyridine; dmap; N,O-bis-(trimethylsilyl)-acetamide; water; triethylamine; trifluoroacetic acid; In tetrahydrofuran; diethyl ether; dichloromethane; 1,2-dichloro-ethane; 1.1: Grignard reaction / 6.2: Vorbrueggen reaction;

DOI:10.1021/jm000073t

upstream raw materials:

4-aminopyrido[2,3-d]pyrimidin-5(8H)-one

1,3-di-O-acetyl-2,5-di-O-benzoyl-3-C-methyl-D-ribofuranose

((3aR,5R,6R,6aR)-6-hydroxy-2,2,6-trimethyltetrahydrofuro[2,3-d][1,3]dioxol-5-yl)methyl benzoate

5-O-benzoyl-1,2-O-isopropylidene-α-D-ribofuranos-3-ulose