16831-81-5Relevant academic research and scientific papers
SELECTIVE INHIBITOR OF PROTEIN ARGININE METHYLTRANSFERASE 5 (PRMT5)
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Paragraph 00311, (2020/08/28)
The disclosure is directed to crystalline forms of the compound of Formula I, pharmaceutically acceptable salts of the compound of Formula I, and crystalline forms thereof. Pharmaceutical compositions comprising said crystalline forms and salts, as well a
SELECTIVE INHIBITORS OF PROTEIN ARGININE METHYLTRANSFERASE 5
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Paragraph 0259, (2020/10/20)
The disclosure is directed to methods of treating disease using compounds of Formula (I).
Selective Inhibitors Of Protein Arginine Methyltransferase 5 (PRMT5)
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Paragraph 0296; 0297, (2019/02/24)
The disclosure is directed to compounds of Formula I Pharmaceutical compositions comprising compounds of Formula I, as well as methods of their use and preparation, are also described.
CD73 INHIBITORS
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Paragraph 00429, (2019/05/22)
Described herein are CD73 inhibitors and pharmaceutical compositions comprising said compounds. The subject compounds and compositions are useful for the treatment of cancer, infections, and neurodegenerative diseases.
CD73 INHIBITORS
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, (2018/12/03)
Described herein are CD73 inhibitors and pharmaceutical compositions comprising said compounds. The subject compounds and compositions are useful for the treatment of cancer, infections, and neurodegenerative diseases.
Revisited 3′-deoxy-3′-C-methyl-β-D-ribonucleoside series
Aljarah, Mohamed,Couturier, Sarah,Gosselin, Gilles,Mathe, Christophe,Perigaud, Christian
, p. 1125 - 1128 (2008/09/17)
The synthesis of some 3′-deoxy-3′-C-methylnucleoside analogues bearing naturally occuring nucleic acid bases was achieved from the preparation of a suitable peracylated 3-deoxy-3-C-methyl sugar using a stereoselective pathway. In addition, examples of chemical modifications at the 2′ position are presented. Copyright Taylor & Francis Group, LLC.
Synthesis of 3′-deoxy-3′-C-methyl-β-d-ribonucleoside analogs
Couturier, Sarah,Aljarah, Mohamed,Gosselin, Gilles,Mathé, Christophe,Périgaud, Christian
, p. 11260 - 11266 (2008/03/12)
3′-Deoxy-3′-C-methyl-β-d-ribonucleoside analogs bearing the five canonical bases of nucleic acids have been synthesized. All these derivatives were prepared by glycosylation of the corresponding heterocyclic bases with a suitable peracylated 3-C-methyl su
Antitumor activity of C-methyl-β-D-ribofuranosyladenine nucleoside ribonucleotide reductase inhibitors
Franchetti, Palmarisa,Cappellacci, Loredana,Pasqualini, Michela,Petrelli, Riccardo,Vita, Patrizia,Jayaram, Hiremagalur N.,Horvath, Zsuzsanna,Szekeres, Thomas,Grifantini, Mario
, p. 4983 - 4989 (2007/10/03)
A series of adenosine derivatives substituted at the 1′-, 2′-, or 3′-position of the ribose ring with a methyl group was synthesized and evaluated for antitumor activity. From this study 3′-C-methyladenosine (3′-Me-Ado) emerged as the most active compound
Synthesis and cytotoxicity of 4-amino-5-oxopyrido[2,3-d]pyrimidine nucleosides
Girardet,Gunic,Esler,Cieslak,Pietrzkowski,Wang
, p. 3704 - 3713 (2007/10/03)
A number of nucleoside analogues have been either used clinically as anticancer drugs or evaluated in clinical studies, while new nucleoside analogues continue to show promise. In this article, we report synthesis and cytotoxicity of a series of new pyrid
SYNTHESIS AND PROPERTIES OF 3'-C-METHYLNUCLEOSIDES AND THEIR PHOSPHORIC ESTERS
Mikhailov, Sergey N.,Beigelman, Leon N.,Gurskaya, Galyna V.,Padyukova, Nelly Sh.,Yakovlev, Gennady I.,Karpeisky, Marat Ya.
, p. 75 - 96 (2007/10/02)
3'-C-Methyluridine and 3'-C-methylcytidine were synthesized in 11 steps starting from D-glucose.The conformation of 3'-C-methylnucleosides was studied in solution and in the cystal by using the techniques of c.d., 1H-n.m.r spectroscopy, and X-ray diffract
