6698-46-0Relevant articles and documents
Stereoselective synthesis of new higher carbon sugars from D-xylose
Liu, Hong-Min,Zou, Da-Peng,Zhang, Fuyi,Zhu, Wei-Guo,Peng, Tao
, p. 2103 - 2106 (2004)
A simple, one-pot multi-step route for the synthesis of a higher carbon sugar 3 by the HDA reaction of a α,β-unsaturated ketone prepared in situ from protected D-xylose with PDC in C6H6 or CH 3CN, followed by the reduction
The Chiron Approach to (3 R,3 aS,6 aR)-Hexahydrofuro[2,3- b]furan-3-ol, a Key Subunit of HIV-1 Protease Inhibitor Drug, Darunavir
Ghosh, Arun K.,Markad, Shivaji B.,Robinson, William L.
, p. 1216 - 1222 (2020/12/22)
We describe an enantioselective synthesis of (3R,3aS,6aR)-hexahydrofuro[2,3-b]furan-3-ol which is a key subunit of darunavir, a widely used HIV-1 protease inhibitor drug for the treatment of HIV/AIDS patients. The synthesis was achieved in optically pure form utilizing commercially available sugar derivatives as the starting material. The key steps involve a highly stereoselective substrate-controlled hydrogenation, a Lewis acid catalyzed anomeric reduction of a 1,2-O-isopropylidene-protected glycofuranoside, and a Baeyer-Villiger oxidation of a tetrahydrofuranyl-2-aldehyde derivative. This optically active ligand alcohol was converted to darunavir efficiently.
SELECTIVE INHIBITORS OF PROTEIN ARGININE METHYLTRANSFERASE 5
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Paragraph 0248, (2020/10/20)
The disclosure is directed to methods of treating disease using compounds of Formula (I).
