N-(2-methylpropyl)-N-{[2-(trifluoromethyl)phenyl]methyl}piperidin-4-amine

Base Information

Chemical Name:N-(2-methylpropyl)-N-{[2-(trifluoromethyl)phenyl]methyl}piperidin-4-amine
CAS No.:710967-96-7
Molecular Formula:C₁₇H₂₅F₃N₂
Molecular Weight:314.394
Hs Code.:

Synonyms:N-(2-methylpropyl)-N-{[2-(trifluoromethyl)phenyl]methyl}piperidin-4-amine

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Chemical Property of N-(2-methylpropyl)-N-{[2-(trifluoromethyl)phenyl]methyl}piperidin-4-amine

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Technology Process of N-(2-methylpropyl)-N-{[2-(trifluoromethyl)phenyl]methyl}piperidin-4-amine

There total 3 articles about N-(2-methylpropyl)-N-{[2-(trifluoromethyl)phenyl]methyl}piperidin-4-amine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 68.0%

: 4-[isobutyl-(2-trifluoromethyl-benzyl)amino]piperidine-l-carboxylic acid tert-butyl ester

: 710967-96-7
N-(2-methylpropyl)-N-{[2-(trifluoromethyl)phenyl]methyl}piperidin-4-amine

Guidance literature:: 4-[isobutyl-(2-trifluoromethyl-benzyl)amino]piperidine-l-carboxylic acid tert-butyl ester; With hydrogenchloride; In ethanol; water; at 20 ℃; for 120h; Acidic aqueous solution;

With hydrogenchloride; In ethanol; water; for 16h; Acidic aqueous solution;

Reference yield: 50.0%

: 710967-96-7
N-(2-methylpropyl)-N-{[2-(trifluoromethyl)phenyl]methyl}piperidin-4-amine

Guidance literature:

Reference yield:

: 710967-99-0
4-(2-trifluoromethylbenzylamino)piperidine-1-carboxylic acid tert-butyl ester

: 78-84-2
isobutyraldehyde

: 710967-96-7
N-(2-methylpropyl)-N-{[2-(trifluoromethyl)phenyl]methyl}piperidin-4-amine

Guidance literature:: 4-(2-trifluoromethylbenzylamino)piperidine-1-carboxylic acid tert-butyl ester; isobutyraldehyde; With sodium tris(acetoxy)borohydride; acetic acid; In 1,2-dichloro-ethane; for 72h; Acidic conditions;

With sodium hydroxide; In water; 1,2-dichloro-ethane; for 0.5h; Alkaline aqueous solution;

With hydrogenchloride; In diethyl ether; ethanol; at 20 ℃; for 24h; Acidic conditions;