(S)-4-(1-benzyl-3-methyl-1H-pyrazol-5-yl)-1-(2,2-diphenylacetyl)piperazine-2-carboxylic acid

Base Information

Chemical Name:(S)-4-(1-benzyl-3-methyl-1H-pyrazol-5-yl)-1-(2,2-diphenylacetyl)piperazine-2-carboxylic acid
CAS No.:1448678-93-0
Molecular Formula:C₃₀H₃₀N₄O₃
Molecular Weight:494.593
Hs Code.:

Synonyms:(S)-4-(1-benzyl-3-methyl-1H-pyrazol-5-yl)-1-(2,2-diphenylacetyl)piperazine-2-carboxylic acid

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Chemical Property of (S)-4-(1-benzyl-3-methyl-1H-pyrazol-5-yl)-1-(2,2-diphenylacetyl)piperazine-2-carboxylic acid

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Technology Process of (S)-4-(1-benzyl-3-methyl-1H-pyrazol-5-yl)-1-(2,2-diphenylacetyl)piperazine-2-carboxylic acid

There total 13 articles about (S)-4-(1-benzyl-3-methyl-1H-pyrazol-5-yl)-1-(2,2-diphenylacetyl)piperazine-2-carboxylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 72.0%

: 1448679-27-3
C₃₁H₃₂N₄O₃

: 1448678-93-0
(S)-4-(1-benzyl-3-methyl-1H-pyrazol-5-yl)-1-(2,2-diphenylacetyl)piperazine-2-carboxylic acid

Guidance literature:: With lithium hydroxide monohydrate; In tetrahydrofuran; water; at 20 ℃; Concentration;

Reference yield:

: 1871-76-7
diphenylacetic acid chloride

: 1448679-29-5
C₁₅H₂₄N₄O₄

: 100-39-0
benzyl bromide

: 1448678-93-0
(S)-4-(1-benzyl-3-methyl-1H-pyrazol-5-yl)-1-(2,2-diphenylacetyl)piperazine-2-carboxylic acid

: 1448678-94-1
(S)-4-(1-benzyl-5-methyl-1H-pyrazol-3-yl)-1-(2,2-diphenylacetyl)piperazine-2-carboxylic acid

Guidance literature:: C₁₅H₂₄N₄O₄; benzyl bromide; With caesium carbonate; In N,N-dimethyl-formamide; at 45 ℃;

With hydrogenchloride; methanol; at 20 ℃; for 3h;

diphenylacetic acid chloride; Further stages;

Reference yield:

: 1448679-21-7
C₁₅H₂₄N₂O₅S

: 1448678-93-0
(S)-4-(1-benzyl-3-methyl-1H-pyrazol-5-yl)-1-(2,2-diphenylacetyl)piperazine-2-carboxylic acid

Guidance literature:: Multi-step reaction with 3 steps

1.1: hydrazine hydrate / toluene / 70 °C

2.1: caesium carbonate / N,N-dimethyl-formamide / 45 °C

2.2: 3 h / 20 °C

2.3: 20 °C

3.1: lithium hydroxide monohydrate / tetrahydrofuran; water / 20 °C

With lithium hydroxide monohydrate; caesium carbonate; hydrazine hydrate; In tetrahydrofuran; water; N,N-dimethyl-formamide; toluene;