Hexadecanoic acid (R)-1-hexadecanoyloxymethyl-2-{methoxy-[(1S,2R,3S,4S,5R,6R)-2,3,4,6-tetrakis-methoxymethoxy-5-(methoxy-methyl-phosphinoyloxy)-cyclohexyloxy]-phosphoryloxy}-ethyl ester

Base Information

Chemical Name:Hexadecanoic acid (R)-1-hexadecanoyloxymethyl-2-{methoxy-[(1S,2R,3S,4S,5R,6R)-2,3,4,6-tetrakis-methoxymethoxy-5-(methoxy-methyl-phosphinoyloxy)-cyclohexyloxy]-phosphoryloxy}-ethyl ester
CAS No.:876310-68-8
Molecular Formula:C₅₂H₁₀₂O₁₉P₂
Molecular Weight:1093.32
Hs Code.:

Hexadecanoic acid (R)-1-hexadecanoyloxymethyl-2-{methoxy-[(1S,2R,3S,4S,5R,6R)-2,3,4,6-tetrakis-methoxymethoxy-5-(methoxy-methyl-phosphinoyloxy)-cyclohexyloxy]-phosphoryloxy}-ethyl ester

Synonyms:Hexadecanoic acid (R)-1-hexadecanoyloxymethyl-2-{methoxy-[(1S,2R,3S,4S,5R,6R)-2,3,4,6-tetrakis-methoxymethoxy-5-(methoxy-methyl-phosphinoyloxy)-cyclohexyloxy]-phosphoryloxy}-ethyl ester

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Chemical Property of Hexadecanoic acid (R)-1-hexadecanoyloxymethyl-2-{methoxy-[(1S,2R,3S,4S,5R,6R)-2,3,4,6-tetrakis-methoxymethoxy-5-(methoxy-methyl-phosphinoyloxy)-cyclohexyloxy]-phosphoryloxy}-ethyl ester

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Technology Process of Hexadecanoic acid (R)-1-hexadecanoyloxymethyl-2-{methoxy-[(1S,2R,3S,4S,5R,6R)-2,3,4,6-tetrakis-methoxymethoxy-5-(methoxy-methyl-phosphinoyloxy)-cyclohexyloxy]-phosphoryloxy}-ethyl ester

There total 3 articles about Hexadecanoic acid (R)-1-hexadecanoyloxymethyl-2-{methoxy-[(1S,2R,3S,4S,5R,6R)-2,3,4,6-tetrakis-methoxymethoxy-5-(methoxy-methyl-phosphinoyloxy)-cyclohexyloxy]-phosphoryloxy}-ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 73.0%

: 876310-65-5
Methyl-phosphonic acid (1S,2S,3S,4S,5R,6S)-3-hydroxy-2,4,5,6-tetrakis-methoxymethoxy-cyclohexyl ester methyl ester

: 496808-59-4
Hexadecanoic acid (R)-2-(diisopropylamino-methoxy-phosphanyloxy)-1-hexadecanoyloxymethyl-ethyl ester

: 876310-68-8
Hexadecanoic acid (R)-1-hexadecanoyloxymethyl-2-{methoxy-[(1S,2R,3S,4S,5R,6R)-2,3,4,6-tetrakis-methoxymethoxy-5-(methoxy-methyl-phosphinoyloxy)-cyclohexyloxy]-phosphoryloxy}-ethyl ester

Guidance literature:: Methyl-phosphonic acid (1S,2S,3S,4S,5R,6S)-3-hydroxy-2,4,5,6-tetrakis-methoxymethoxy-cyclohexyl ester methyl ester; Hexadecanoic acid (R)-2-(diisopropylamino-methoxy-phosphanyloxy)-1-hexadecanoyloxymethyl-ethyl ester; With 1H-tetrazole; In tetrahydrofuran; dichloromethane; at 20 ℃; for 20h;

With tetrabutylammonium periodite; In tetrahydrofuran; dichloromethane; at -20 - 20 ℃; for 1.5h;
DOI:10.1021/ja0554716

Reference yield:

: 876310-63-3
Methyl-phosphonic acid (1R,2S,3S,4R,5R,6S)-3-(tert-butyl-diphenyl-silanyloxy)-2,4,5,6-tetrakis-methoxymethoxy-cyclohexyl ester methyl ester

: 876310-68-8
Hexadecanoic acid (R)-1-hexadecanoyloxymethyl-2-{methoxy-[(1S,2R,3S,4S,5R,6R)-2,3,4,6-tetrakis-methoxymethoxy-5-(methoxy-methyl-phosphinoyloxy)-cyclohexyloxy]-phosphoryloxy}-ethyl ester

Guidance literature:: Multi-step reaction with 2 steps

1.1: 77 percent / tetrabutylammonium fluoride trihydrate / tetrahydrofuran / 18 h / 20 °C

2.1: 1H-tetrazole / CH₂Cl₂; tetrahydrofuran / 20 h / 20 °C

2.2: 73 percent / n-Bu₄NIO₄ / CH₂Cl₂; tetrahydrofuran / 1.5 h / -20 - 20 °C

With 1H-tetrazole; tetrabutyl ammonium fluoride; In tetrahydrofuran; dichloromethane;
DOI:10.1021/ja0554716

Reference yield:

: 30334-71-5
1,2-dipalmitoyl-sn-glycerol

: 876310-68-8
Hexadecanoic acid (R)-1-hexadecanoyloxymethyl-2-{methoxy-[(1S,2R,3S,4S,5R,6R)-2,3,4,6-tetrakis-methoxymethoxy-5-(methoxy-methyl-phosphinoyloxy)-cyclohexyloxy]-phosphoryloxy}-ethyl ester

Guidance literature:: Multi-step reaction with 2 steps

1.1: DIPEA / CH₂Cl₂

2.1: 1H-tetrazole / CH₂Cl₂; tetrahydrofuran / 20 h / 20 °C

2.2: 73 percent / n-Bu₄NIO₄ / CH₂Cl₂; tetrahydrofuran / 1.5 h / -20 - 20 °C

With 1H-tetrazole; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; dichloromethane;
DOI:10.1021/ja0554716