(S)-1-((1-((3,5-di-tert-butyl-4-methoxyphenyl)sulfonyl)-4,4-dimethylpyrrolidin-2-yl)methoxy)-2,2,6,6-tetramethylpiperidine

Base Information

Chemical Name:(S)-1-((1-((3,5-di-tert-butyl-4-methoxyphenyl)sulfonyl)-4,4-dimethylpyrrolidin-2-yl)methoxy)-2,2,6,6-tetramethylpiperidine
CAS No.:1416916-82-9
Molecular Formula:C₃₁H₅₄N₂O₄S
Molecular Weight:550.847
Hs Code.:

Synonyms:(S)-1-((1-((3,5-di-tert-butyl-4-methoxyphenyl)sulfonyl)-4,4-dimethylpyrrolidin-2-yl)methoxy)-2,2,6,6-tetramethylpiperidine

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Chemical Property of (S)-1-((1-((3,5-di-tert-butyl-4-methoxyphenyl)sulfonyl)-4,4-dimethylpyrrolidin-2-yl)methoxy)-2,2,6,6-tetramethylpiperidine

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Technology Process of (S)-1-((1-((3,5-di-tert-butyl-4-methoxyphenyl)sulfonyl)-4,4-dimethylpyrrolidin-2-yl)methoxy)-2,2,6,6-tetramethylpiperidine

There total 3 articles about (S)-1-((1-((3,5-di-tert-butyl-4-methoxyphenyl)sulfonyl)-4,4-dimethylpyrrolidin-2-yl)methoxy)-2,2,6,6-tetramethylpiperidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 88.0%

: 2564-83-2
2,2,6,6-tetramethyl-piperidine-N-oxyl

: 1416916-78-3
3,5-di-tert-butyl-N-(2,2-dimethylpent-4-en-1-yl)-4-methoxybenzenesulfonamide

: 1416916-82-9
(S)-1-((1-((3,5-di-tert-butyl-4-methoxyphenyl)sulfonyl)-4,4-dimethylpyrrolidin-2-yl)methoxy)-2,2,6,6-tetramethylpiperidine

Guidance literature:: With α,α,α-trifluorotoluene; oxygen; copper(II) bis(trifluoromethanesulfonate); potassium carbonate; (4R,4'R)-2,2'-(propane-2,2'diyl)bis(4-phenyl-4,5-dihydrooxazole); at 20 - 110 ℃; for 6h; under 760.051 Torr; enantioselective reaction;
DOI:10.1021/jo3023632

Reference yield:

: 160252-94-8
3,5-di-tert-butyl-4-methoxybenzene-1-sulfonyl chloride

: 1416916-82-9
(S)-1-((1-((3,5-di-tert-butyl-4-methoxyphenyl)sulfonyl)-4,4-dimethylpyrrolidin-2-yl)methoxy)-2,2,6,6-tetramethylpiperidine

Guidance literature:: Multi-step reaction with 2 steps

1: triethylamine / dichloromethane / 20 °C

2: oxygen; (4R,4'R)-2,2'-(propane-2,2'diyl)bis(4-phenyl-4,5-dihydrooxazole); α,α,α-trifluorotoluene; copper(II) bis(trifluoromethanesulfonate); potassium carbonate / 6 h / 20 - 110 °C / 760.05 Torr

With α,α,α-trifluorotoluene; oxygen; copper(II) bis(trifluoromethanesulfonate); potassium carbonate; triethylamine; (4R,4'R)-2,2'-(propane-2,2'diyl)bis(4-phenyl-4,5-dihydrooxazole); In dichloromethane;
DOI:10.1021/jo3023632

Reference yield:

: 73604-46-3
2,2-dimethyl-1-amino-pent-4-ene

: 1416916-82-9
(S)-1-((1-((3,5-di-tert-butyl-4-methoxyphenyl)sulfonyl)-4,4-dimethylpyrrolidin-2-yl)methoxy)-2,2,6,6-tetramethylpiperidine

Guidance literature:: Multi-step reaction with 2 steps

1: triethylamine / dichloromethane / 20 °C

2: oxygen; (4R,4'R)-2,2'-(propane-2,2'diyl)bis(4-phenyl-4,5-dihydrooxazole); α,α,α-trifluorotoluene; copper(II) bis(trifluoromethanesulfonate); potassium carbonate / 6 h / 20 - 110 °C / 760.05 Torr

With α,α,α-trifluorotoluene; oxygen; copper(II) bis(trifluoromethanesulfonate); potassium carbonate; triethylamine; (4R,4'R)-2,2'-(propane-2,2'diyl)bis(4-phenyl-4,5-dihydrooxazole); In dichloromethane;
DOI:10.1021/jo3023632