Technology Process of YM-234903
There total 4 articles about YM-234903 which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
ethyl (R)-1-{2-[(4-fluorobenzoyl)amino]ethyl}piperidine-3-carboxylate;
With
sodium hydroxide; ethanol; water;
at 25 ℃;
for 2h;
Industry scale;
With
hydrogenchloride;
pH=3.0 - 3.06;
Product distribution / selectivity;
Industry scale;
- Guidance literature:
-
Multi-step reaction with 4 steps
1: potassium carbonate / water; ethyl acetate / 1 h / -5 - 5 °C / Large scale
2: potassium carbonate / water; ethyl acetate / 4 h / 45 - 52 °C / Large scale
3: toluene-4-sulfonic acid / ethyl acetate; toluene / 32 h / Reflux; Large scale
4: sodium hydroxide / water; ethanol / 2 h / 25 °C / Large scale
With
potassium carbonate; toluene-4-sulfonic acid; sodium hydroxide;
In
ethanol; water; ethyl acetate; toluene;
1: |Schotten-Baumann Reaction;
DOI:10.1021/op5002885
- Guidance literature:
-
Multi-step reaction with 2 steps
1: toluene-4-sulfonic acid / ethyl acetate; toluene / 32 h / Reflux; Large scale
2: sodium hydroxide / water; ethanol / 2 h / 25 °C / Large scale
With
toluene-4-sulfonic acid; sodium hydroxide;
In
ethanol; water; ethyl acetate; toluene;
DOI:10.1021/op5002885