721452-52-4

Upstream product

• 1221792-32-0 C₁₀H₂₀N₂O₂ 
• 403-43-0 4-fluorobenzoyl chloride 
• 95383-37-2 2-bromo-1-(4-fluorobenzamido)ethane 
• 25137-01-3 (R)-ethyl nipecotate 

Downstream Products

• 312752-85-5 [14C]-YM₇₅₈ 
• 312752-86-6 [3H]-YM₇₅₈ monophosphate 
• 721452-55-7 YM-234903 

Relevant academic research and scientific papers

Development of a practical and scalable synthetic route to YM758 monophosphate, a novel If channel inhibitor

A novel, practical, and efficient synthesis of (-)-N-{2-[(R)-3-(6,7-dimethoxy-1,2,3,4-tetrahydroisoquinoline-2-carbonyl)piperidino]ethyl}-4-fluorobenzamide monophosphate (YM758 monophosphate, (R)-1·H3PO4 (Figure 1) is described. The

Novel denzamide derivatives and process for production thereof

There are provided a novel process for the production of an isoquinoline derivative having an inhibitory action for If current; a novel benzamide derivative or a salt thereof used for the production process; and a process for the production of the benzamide derivative or a salt thereof.

NOVEL CRYSTAL OF FLUOROBENZAMIDE DERIVATIVE

There are provided novel crystals of (-)-N-{2-[(R)-3-(6,7-dimethoxy-1,2,3,4-tetrahydroisoquinoline-2-carbonyl)piperidino]ethyl}-4-fluorobenzamide monophosphate.