N-(4,4-dibromo-3-butenyl)-N-(3-propynyl)-p-toluenesulfonamide

Base Information

• Chemical Name: N-(4,4-dibromo-3-butenyl)-N-(3-propynyl)-p-toluenesulfonamide
• CAS No.: 187887-02-1
• Molecular Formula: C₁₄H₁₅Br₂NO₂S
• Molecular Weight: 421.153
• Mol file: 187887-02-1.mol

Synonyms:N-(4,4-dibromo-3-butenyl)-N-(3-propynyl)-p-toluenesulfonamide

Chemical Property of N-(4,4-dibromo-3-butenyl)-N-(3-propynyl)-p-toluenesulfonamide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of N-(4,4-dibromo-3-butenyl)-N-(3-propynyl)-p-toluenesulfonamide

There total 3 articles about N-(4,4-dibromo-3-butenyl)-N-(3-propynyl)-p-toluenesulfonamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 88.0%

carbon tetrabromide (558-13-4) + N-(2-formylethyl)-N-(3-propynyl)-p-toluenesulfonamide (152453-96-8) → N-(4,4-dibromo-3-butenyl)-N-(3-propynyl)-p-toluenesulfonamide (187887-02-1)

Guidance literature:

With triphenylphosphine; In dichloromethane; at 0 ℃; for 0.0833333h;

DOI:10.3987/com-96-s43

Reference yield:

4-methyl-N-prop-2-ynylbenzenesulfonamide (55022-46-3) → N-(4,4-dibromo-3-butenyl)-N-(3-propynyl)-p-toluenesulfonamide (187887-02-1)

Guidance literature:

Multi-step reaction with 3 steps

1: 1.) NaH; 2.) HCl / 1.) THF, oil, DMF, 45 deg C, 2 h; 2.) THF, DMF, H₂O, r.t., 1 h

2: 89 percent / PCC, MS 4A / CH₂Cl₂ / 1 h / Ambient temperature

3: 88 percent / PPh₃ / CH₂Cl₂ / 0.08 h / 0 °C

With hydrogenchloride; sodium hydride; triphenylphosphine; pyridinium chlorochromate; In dichloromethane;

DOI:10.3987/com-96-s43

Reference yield:

N-(3-hydroxypropyl)-4-methyl-N-prop-2-ynylbenzenesulfonamide (187887-01-0) → N-(4,4-dibromo-3-butenyl)-N-(3-propynyl)-p-toluenesulfonamide (187887-02-1)

Guidance literature:

Multi-step reaction with 2 steps

1: 89 percent / PCC, MS 4A / CH₂Cl₂ / 1 h / Ambient temperature

2: 88 percent / PPh₃ / CH₂Cl₂ / 0.08 h / 0 °C

With triphenylphosphine; pyridinium chlorochromate; In dichloromethane;

DOI:10.3987/com-96-s43

upstream raw materials:

carbon tetrabromide

N-(2-formylethyl)-N-(3-propynyl)-p-toluenesulfonamide

4-methyl-N-prop-2-ynylbenzenesulfonamide

N-(3-hydroxypropyl)-4-methyl-N-prop-2-ynylbenzenesulfonamide

Downstream raw materials:

N-(3-butynyl)-4-methyl-N-(2-propynyl)benzenosulfonamide

2-tosyl-1,2,3,4-tetrahydroisoquinoline