benzyl (4-{[({3-fluoro-4-[(2-phenylethyl)amino]-1,1'-biphenyl-2-yl}acetyl)amino]methyl}phenyl)(imino)methylcarbamate

Base Information

Chemical Name:benzyl (4-{[({3-fluoro-4-[(2-phenylethyl)amino]-1,1'-biphenyl-2-yl}acetyl)amino]methyl}phenyl)(imino)methylcarbamate
CAS No.:361336-97-2
Molecular Formula:C₃₈H₃₅FN₄O₃
Molecular Weight:614.719
Hs Code.:

Synonyms:benzyl (4-{[({3-fluoro-4-[(2-phenylethyl)amino]-1,1'-biphenyl-2-yl}acetyl)amino]methyl}phenyl)(imino)methylcarbamate

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Chemical Property of benzyl (4-{[({3-fluoro-4-[(2-phenylethyl)amino]-1,1'-biphenyl-2-yl}acetyl)amino]methyl}phenyl)(imino)methylcarbamate

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Technology Process of benzyl (4-{[({3-fluoro-4-[(2-phenylethyl)amino]-1,1'-biphenyl-2-yl}acetyl)amino]methyl}phenyl)(imino)methylcarbamate

There total 11 articles about benzyl (4-{[({3-fluoro-4-[(2-phenylethyl)amino]-1,1'-biphenyl-2-yl}acetyl)amino]methyl}phenyl)(imino)methylcarbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

: benzyl ((4-(aminomethyl)phenyl)(imino)methyl)carbamate hydrochloride

: 361336-96-1
{3-fluoro-4-[(2-phenylethyl)amino]-1,1'-biphenyl-2-yl}acetic acid

: 361336-97-2
benzyl (4-{[({3-fluoro-4-[(2-phenylethyl)amino]-1,1'-biphenyl-2-yl}acetyl)amino]methyl}phenyl)(imino)methylcarbamate

Guidance literature:: {3-fluoro-4-[(2-phenylethyl)amino]-1,1'-biphenyl-2-yl}acetic acid; With PS-carbodiimide; benzotriazol-1-ol; In dichloromethane; N,N-dimethyl-formamide; for 0.25h;

benzyl ((4-(aminomethyl)phenyl)(imino)methyl)carbamate hydrochloride; With 4-methyl-morpholine; In dichloromethane; N,N-dimethyl-formamide;
DOI:10.1021/jm030233b

Reference yield:

: 960-16-7
tributylphenylstannane

: 361336-97-2
benzyl (4-{[({3-fluoro-4-[(2-phenylethyl)amino]-1,1'-biphenyl-2-yl}acetyl)amino]methyl}phenyl)(imino)methylcarbamate

Guidance literature:: Multi-step reaction with 5 steps

1.1: 78 percent / (Ph₃P)4Pd; LiCl / dioxane / 85 °C

2.1: 91 percent / Fe; glacial AcOH / 80 °C

3.1: 80 percent / NaHB(OAc)3; AcOH / tetrahydrofuran; CH₂Cl₂ / 20 °C

4.1: 84 percent / aq. NaOH / methanol / 65 °C

5.1: 1-hydroxybenzotriazole; PS-carbodiimide / CH₂Cl₂; dimethylformamide / 0.25 h

5.2: 96 percent / N-methylmorpholine / CH₂Cl₂; dimethylformamide

With sodium hydroxide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; PS-carbodiimide; sodium tris(acetoxy)borohydride; iron; benzotriazol-1-ol; acetic acid; lithium chloride; In tetrahydrofuran; 1,4-dioxane; methanol; dichloromethane; N,N-dimethyl-formamide; 1.1: Stille coupling;
DOI:10.1021/jm030233b

Reference yield:

: 85068-28-6
2,6-difluorophenylacetic acid

: 361336-97-2
benzyl (4-{[({3-fluoro-4-[(2-phenylethyl)amino]-1,1'-biphenyl-2-yl}acetyl)amino]methyl}phenyl)(imino)methylcarbamate

Guidance literature:: Multi-step reaction with 10 steps

1.1: 91 percent / HNO₃ / methanol / 0.25 h / -10 °C

2.1: oxalyl chloride; DMF / CH₂Cl₂ / 20 °C

3.1: 5.47 g / pyridine / CH₂Cl₂ / 20 °C

4.1: 27 percent / trimethylacetic acid; K₂CO₃ / dimethylsulfoxide / 0.25 h / 80 °C

5.1: 68 percent / Et₃N / CH₂Cl₂ / 20 °C

6.1: 78 percent / (Ph₃P)4Pd; LiCl / dioxane / 85 °C

7.1: 91 percent / Fe; glacial AcOH / 80 °C

8.1: 80 percent / NaHB(OAc)3; AcOH / tetrahydrofuran; CH₂Cl₂ / 20 °C

9.1: 84 percent / aq. NaOH / methanol / 65 °C

10.1: 1-hydroxybenzotriazole; PS-carbodiimide / CH₂Cl₂; dimethylformamide / 0.25 h

10.2: 96 percent / N-methylmorpholine / CH₂Cl₂; dimethylformamide

With pyridine; sodium hydroxide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; PS-carbodiimide; oxalyl dichloride; nitric acid; sodium tris(acetoxy)borohydride; iron; potassium carbonate; benzotriazol-1-ol; acetic acid; triethylamine; N,N-dimethyl-formamide; lithium chloride; Trimethylacetic acid; In tetrahydrofuran; 1,4-dioxane; methanol; dichloromethane; dimethyl sulfoxide; N,N-dimethyl-formamide; 6.1: Stille coupling;
DOI:10.1021/jm030233b