ethyl 3-(2-carbamoylethyl)-5-[(4-fluorophenyl)methyl]-benzenepropanoate

Base Information

Chemical Name:ethyl 3-(2-carbamoylethyl)-5-[(4-fluorophenyl)methyl]-benzenepropanoate
CAS No.:161778-35-4
Molecular Formula:C₂₁H₂₄FNO₃
Molecular Weight:357.425
Hs Code.:

Synonyms:ethyl 3-(2-carbamoylethyl)-5-[(4-fluorophenyl)methyl]-benzenepropanoate

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Chemical Property of ethyl 3-(2-carbamoylethyl)-5-[(4-fluorophenyl)methyl]-benzenepropanoate

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Technology Process of ethyl 3-(2-carbamoylethyl)-5-[(4-fluorophenyl)methyl]-benzenepropanoate

There total 11 articles about ethyl 3-(2-carbamoylethyl)-5-[(4-fluorophenyl)methyl]-benzenepropanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 79-37-8
oxalyl dichloride

: 161778-30-9
monoethyl 5-[(4-fluorophenyl)methyl]-1,3-benzenedipropanoate

: 161778-35-4
ethyl 3-(2-carbamoylethyl)-5-[(4-fluorophenyl)methyl]-benzenepropanoate

Guidance literature:: With ammonia; In diethyl ether; dichloromethane; ethyl acetate; N,N-dimethyl-formamide;

Reference yield:

: 626-39-1
1,3,5-trisbromobenzene

: 161778-35-4
ethyl 3-(2-carbamoylethyl)-5-[(4-fluorophenyl)methyl]-benzenepropanoate

Guidance literature:: Multi-step reaction with 6 steps

1: 1.) n-BuLi / 1.) Et₂O, 2.) Et₂O

2: 89 percent / Pd(OAc)2, P(o-Tol)3, Et₃N / acetonitrile / Heating

3: 96 percent / pyridine, DMAP

4: 99 percent / H₂ / Pd/C / ethyl acetate

5: 52 percent / aq. NaOH / ethanol

6: 1.) (COCl)2, 2.) NH₄OH / 1.) CH₂Cl₂

With pyridine; dmap; palladium diacetate; ammonium hydroxide; sodium hydroxide; n-butyllithium; oxalyl dichloride; hydrogen; triethylamine; tris-(o-tolyl)phosphine; palladium on activated charcoal; In ethanol; ethyl acetate; acetonitrile;
DOI:10.1016/S0960-894X(98)00242-X

Reference yield:

: 161777-98-6
3,5-dibromo-α-(4-fluorophenyl)benzenemethanol

: 161778-35-4
ethyl 3-(2-carbamoylethyl)-5-[(4-fluorophenyl)methyl]-benzenepropanoate

Guidance literature:: Multi-step reaction with 5 steps

1: 89 percent / Pd(OAc)2, P(o-Tol)3, Et₃N / acetonitrile / Heating

2: 96 percent / pyridine, DMAP

3: 99 percent / H₂ / Pd/C / ethyl acetate

4: 52 percent / aq. NaOH / ethanol

5: 1.) (COCl)2, 2.) NH₄OH / 1.) CH₂Cl₂

With pyridine; dmap; palladium diacetate; ammonium hydroxide; sodium hydroxide; oxalyl dichloride; hydrogen; triethylamine; tris-(o-tolyl)phosphine; palladium on activated charcoal; In ethanol; ethyl acetate; acetonitrile;
DOI:10.1016/S0960-894X(98)00242-X