Technology Process of ethyl 3-(2-carbamoylethyl)-5-[(4-fluorophenyl)methyl]-benzenepropanoate
There total 11 articles about ethyl 3-(2-carbamoylethyl)-5-[(4-fluorophenyl)methyl]-benzenepropanoate which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
ammonia;
In
diethyl ether; dichloromethane; ethyl acetate; N,N-dimethyl-formamide;
- Guidance literature:
-
Multi-step reaction with 6 steps
1: 1.) n-BuLi / 1.) Et2O, 2.) Et2O
2: 89 percent / Pd(OAc)2, P(o-Tol)3, Et3N / acetonitrile / Heating
3: 96 percent / pyridine, DMAP
4: 99 percent / H2 / Pd/C / ethyl acetate
5: 52 percent / aq. NaOH / ethanol
6: 1.) (COCl)2, 2.) NH4OH / 1.) CH2Cl2
With
pyridine; dmap; palladium diacetate; ammonium hydroxide; sodium hydroxide; n-butyllithium; oxalyl dichloride; hydrogen; triethylamine; tris-(o-tolyl)phosphine;
palladium on activated charcoal;
In
ethanol; ethyl acetate; acetonitrile;
DOI:10.1016/S0960-894X(98)00242-X
- Guidance literature:
-
Multi-step reaction with 5 steps
1: 89 percent / Pd(OAc)2, P(o-Tol)3, Et3N / acetonitrile / Heating
2: 96 percent / pyridine, DMAP
3: 99 percent / H2 / Pd/C / ethyl acetate
4: 52 percent / aq. NaOH / ethanol
5: 1.) (COCl)2, 2.) NH4OH / 1.) CH2Cl2
With
pyridine; dmap; palladium diacetate; ammonium hydroxide; sodium hydroxide; oxalyl dichloride; hydrogen; triethylamine; tris-(o-tolyl)phosphine;
palladium on activated charcoal;
In
ethanol; ethyl acetate; acetonitrile;
DOI:10.1016/S0960-894X(98)00242-X
