Technology Process of (3R)-3-{[tert-butyl(dimethyl)silyl]oxy}-7-phenylheptyl pivalate
There total 5 articles about (3R)-3-{[tert-butyl(dimethyl)silyl]oxy}-7-phenylheptyl pivalate which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
(3R)-3-hydroxy-7-phenylheptyl pivalate; tert-butyldimethylsilyl chloride;
With
1H-imidazole;
In
dichloromethane;
at 0 ℃;
for 0.0833333h;
With
dmap;
In
dichloromethane;
at 20 ℃;
for 1h;
DOI:10.1055/s-0030-1260214
- Guidance literature:
-
Multi-step reaction with 4 steps
1.1: titanium(IV) isopropylate; diethyl (2S,3S)-tartrate / dichloromethane / 0.5 h / -20 °C / Molecular sieve
1.2: 12 h / -20 °C
2.1: sodium bis(2-methoxyethoxy)aluminium dihydride / tetrahydrofuran; toluene / 3 h / 0 °C
3.1: pyridine / dichloromethane / 0 - 20 °C
4.1: 1H-imidazole / dichloromethane / 0.08 h / 0 °C
4.2: 1 h / 20 °C
With
pyridine; 1H-imidazole; titanium(IV) isopropylate; diethyl (2S,3S)-tartrate; sodium bis(2-methoxyethoxy)aluminium dihydride;
In
tetrahydrofuran; dichloromethane; toluene;
1.1: Sharpless asymmetric epoxidation / 1.2: Sharpless asymmetric epoxidation;
DOI:10.1055/s-0030-1260214
- Guidance literature:
-
Multi-step reaction with 3 steps
1.1: sodium bis(2-methoxyethoxy)aluminium dihydride / tetrahydrofuran; toluene / 3 h / 0 °C
2.1: pyridine / dichloromethane / 0 - 20 °C
3.1: 1H-imidazole / dichloromethane / 0.08 h / 0 °C
3.2: 1 h / 20 °C
With
pyridine; 1H-imidazole; sodium bis(2-methoxyethoxy)aluminium dihydride;
In
tetrahydrofuran; dichloromethane; toluene;
DOI:10.1055/s-0030-1260214
