(3R)-3-{[tert-butyl(dimethyl)silyl]oxy}-7-phenylheptan-1-ol

Base Information

• Chemical Name: (3R)-3-{[tert-butyl(dimethyl)silyl]oxy}-7-phenylheptan-1-ol
• CAS No.: 1009359-55-0
• Molecular Formula: C₁₉H₃₄O₂Si
• Molecular Weight: 322.563
• Mol file: 1009359-55-0.mol

Synonyms:(3R)-3-{[tert-butyl(dimethyl)silyl]oxy}-7-phenylheptan-1-ol

Chemical Property of (3R)-3-{[tert-butyl(dimethyl)silyl]oxy}-7-phenylheptan-1-ol

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (3R)-3-{[tert-butyl(dimethyl)silyl]oxy}-7-phenylheptan-1-ol

There total 8 articles about (3R)-3-{[tert-butyl(dimethyl)silyl]oxy}-7-phenylheptan-1-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

(3R)-3-{[tert-butyl(dimethyl)silyl]oxy}-7-phenylheptyl pivalate (1353654-07-5) → (3R)-3-{[tert-butyl(dimethyl)silyl]oxy}-7-phenylheptan-1-ol (1009359-55-0)

Guidance literature:

With diisobutylaluminium hydride; In tetrahydrofuran; at -78 ℃; for 0.5h;

DOI:10.1055/s-0030-1260214

Reference yield: 87.0%

{(1R)-1-[2-(benzyloxy)ethyl]-5-phenylpentyloxy}(tert-butyl)dimethylsilane (1009359-53-8) → (3R)-3-{[tert-butyl(dimethyl)silyl]oxy}-7-phenylheptan-1-ol (1009359-55-0)

Guidance literature:

With hydrogen; palladium on activated charcoal; In ethyl acetate; at 20 ℃; for 6h;

DOI:10.1055/s-2007-990928

Reference yield:

benzoic acid 3-hydroxy-7-phenyl-heptyl ester → (3R)-3-{[tert-butyl(dimethyl)silyl]oxy}-7-phenylheptan-1-ol (1009359-55-0)

Guidance literature:

Multi-step reaction with 2 steps

1: imidazole / CH₂Cl₂ / 20 °C

2: Alkaline hydrolysis

With 1H-imidazole; In dichloromethane;

DOI:10.1016/j.tetlet.2007.01.056

upstream raw materials:

{(1R)-1-[2-(benzyloxy)ethyl]-5-phenylpentyloxy}(tert-butyl)dimethylsilane

ethyl (2E)-7-phenylhept-2-enoate

(3R)-3-hydroxy-7-phenylheptyl pivalate

(3R)-7-phenylheptane-1,3-diol

Downstream raw materials:

(3R)-3-[tert-butyl(dimethyl)silyloxy]-7-phenylheptanal

[(2R,3R)-3-((2R)-2-{[tert-butyl(dimethyl)silyl]oxy}-6-phenylhexyl)oxiran-2-yl]methanol

(3S,5R)-5-{[tert-butyl(dimethyl)silyl]oxy}-9-phenylnonane-1,3-diol

(3S,5R)-3,5-bis{[tert-butyl(dimethyl)silyl]oxy}-9-phenylnonyl pivalate