1-{3-fluoro-4-[6-methoxy-7-(2-methyl-octahydro-cyclopenta[c]pyrrole-5-ylmethoxy)-quinazolin-4-yloxy]-phenyl}-3-phenylacetyl-thiourea hydrochloride

Base Information

Chemical Name:1-{3-fluoro-4-[6-methoxy-7-(2-methyl-octahydro-cyclopenta[c]pyrrole-5-ylmethoxy)-quinazolin-4-yloxy]-phenyl}-3-phenylacetyl-thiourea hydrochloride
CAS No.:849217-37-4
Molecular Formula:C₃₃H₃₄FN₅O₄S*ClH
Molecular Weight:652.189
Hs Code.:

1-{3-fluoro-4-[6-methoxy-7-(2-methyl-octahydro-cyclopenta[c]pyrrole-5-ylmethoxy)-quinazolin-4-yloxy]-phenyl}-3-phenylacetyl-thiourea hydrochloride

Synonyms:1-{3-fluoro-4-[6-methoxy-7-(2-methyl-octahydro-cyclopenta[c]pyrrole-5-ylmethoxy)-quinazolin-4-yloxy]-phenyl}-3-phenylacetyl-thiourea hydrochloride

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Chemical Property of 1-{3-fluoro-4-[6-methoxy-7-(2-methyl-octahydro-cyclopenta[c]pyrrole-5-ylmethoxy)-quinazolin-4-yloxy]-phenyl}-3-phenylacetyl-thiourea hydrochloride

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Technology Process of 1-{3-fluoro-4-[6-methoxy-7-(2-methyl-octahydro-cyclopenta[c]pyrrole-5-ylmethoxy)-quinazolin-4-yloxy]-phenyl}-3-phenylacetyl-thiourea hydrochloride

There total 4 articles about 1-{3-fluoro-4-[6-methoxy-7-(2-methyl-octahydro-cyclopenta[c]pyrrole-5-ylmethoxy)-quinazolin-4-yloxy]-phenyl}-3-phenylacetyl-thiourea hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 849217-36-3
1-{3-fluoro-4-[6-methoxy-7-(2-methyl-octahydro-cyclopenta[c]pyrrole-5-ylmethoxy)-quinazolin-4-yloxy]-phenyl}-3-phenylacetyl-thiourea

: 849217-37-4
1-{3-fluoro-4-[6-methoxy-7-(2-methyl-octahydro-cyclopenta[c]pyrrole-5-ylmethoxy)-quinazolin-4-yloxy]-phenyl}-3-phenylacetyl-thiourea hydrochloride

Guidance literature:: With hydrogenchloride; In water; acetonitrile;

Reference yield:

: 849217-33-0
5-(4-chloro-6-methoxy-quinazolin-7-yloxymethyl)-hexahydro-cyclopenta[c]pyrrole-2-carboxylic acid benzyl ester

: 849217-37-4
1-{3-fluoro-4-[6-methoxy-7-(2-methyl-octahydro-cyclopenta[c]pyrrole-5-ylmethoxy)-quinazolin-4-yloxy]-phenyl}-3-phenylacetyl-thiourea hydrochloride

Guidance literature:: Multi-step reaction with 5 steps

1.1: sodium hydride / N,N-dimethyl-formamide / 20 °C

1.2: 1 - 2 h / 20 °C

2.1: ethanol; toluene / 1 - 2 h / 20 °C

3.1: hydrogen bromide; acetic acid / 1 h / 20 °C

4.1: sodium tris(acetoxy)borohydride; acetic acid / water; acetonitrile / 3 h / 0 - 20 °C

5.1: hydrogenchloride / water; acetonitrile

With hydrogenchloride; hydrogen bromide; sodium tris(acetoxy)borohydride; sodium hydride; acetic acid; In ethanol; water; N,N-dimethyl-formamide; toluene; acetonitrile;

Reference yield:

: 103-80-0
phenylacetyl chloride

: 849217-37-4
1-{3-fluoro-4-[6-methoxy-7-(2-methyl-octahydro-cyclopenta[c]pyrrole-5-ylmethoxy)-quinazolin-4-yloxy]-phenyl}-3-phenylacetyl-thiourea hydrochloride

Guidance literature:: Multi-step reaction with 5 steps

1: toluene / 2 h / Heating / reflux

2: ethanol; toluene / 1 - 2 h / 20 °C

3: hydrogen bromide; acetic acid / 1 h / 20 °C

4: sodium tris(acetoxy)borohydride; acetic acid / water; acetonitrile / 3 h / 0 - 20 °C

5: hydrogenchloride / water; acetonitrile

With hydrogenchloride; hydrogen bromide; sodium tris(acetoxy)borohydride; acetic acid; In ethanol; water; toluene; acetonitrile;