1-{3-fluoro-4-[6-methoxy-7-(2-methyl-octahydro-cyclopenta[c]pyrrole-5-ylmethoxy)-quinazolin-4-yloxy]-phenyl}-3-phenylacetyl-thiourea

Base Information

Chemical Name:1-{3-fluoro-4-[6-methoxy-7-(2-methyl-octahydro-cyclopenta[c]pyrrole-5-ylmethoxy)-quinazolin-4-yloxy]-phenyl}-3-phenylacetyl-thiourea
CAS No.:849217-36-3
Molecular Formula:C₃₃H₃₄FN₅O₄S
Molecular Weight:615.728
Hs Code.:

Synonyms:1-{3-fluoro-4-[6-methoxy-7-(2-methyl-octahydro-cyclopenta[c]pyrrole-5-ylmethoxy)-quinazolin-4-yloxy]-phenyl}-3-phenylacetyl-thiourea

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Chemical Property of 1-{3-fluoro-4-[6-methoxy-7-(2-methyl-octahydro-cyclopenta[c]pyrrole-5-ylmethoxy)-quinazolin-4-yloxy]-phenyl}-3-phenylacetyl-thiourea

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Technology Process of 1-{3-fluoro-4-[6-methoxy-7-(2-methyl-octahydro-cyclopenta[c]pyrrole-5-ylmethoxy)-quinazolin-4-yloxy]-phenyl}-3-phenylacetyl-thiourea

There total 3 articles about 1-{3-fluoro-4-[6-methoxy-7-(2-methyl-octahydro-cyclopenta[c]pyrrole-5-ylmethoxy)-quinazolin-4-yloxy]-phenyl}-3-phenylacetyl-thiourea which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 40.0%

: 50-00-0,30525-89-4,61233-19-0
formaldehyd

: 1-{3-fluoro-4-[6-methoxy-7-(octahydro-cyclopenta[c]pyrrole-5-ylmethoxy)-quinazolin-4-yloxy]-phenyl}-3-phenylacetyl-thiourea dihydrobromide

: 849217-36-3
1-{3-fluoro-4-[6-methoxy-7-(2-methyl-octahydro-cyclopenta[c]pyrrole-5-ylmethoxy)-quinazolin-4-yloxy]-phenyl}-3-phenylacetyl-thiourea

Guidance literature:: With sodium tris(acetoxy)borohydride; acetic acid; In water; acetonitrile; at 0 - 20 ℃; for 3h;

Reference yield:

: 849217-33-0
5-(4-chloro-6-methoxy-quinazolin-7-yloxymethyl)-hexahydro-cyclopenta[c]pyrrole-2-carboxylic acid benzyl ester

: 849217-36-3
1-{3-fluoro-4-[6-methoxy-7-(2-methyl-octahydro-cyclopenta[c]pyrrole-5-ylmethoxy)-quinazolin-4-yloxy]-phenyl}-3-phenylacetyl-thiourea

Guidance literature:: Multi-step reaction with 4 steps

1.1: sodium hydride / N,N-dimethyl-formamide / 20 °C

1.2: 1 - 2 h / 20 °C

2.1: ethanol; toluene / 1 - 2 h / 20 °C

3.1: hydrogen bromide; acetic acid / 1 h / 20 °C

4.1: sodium tris(acetoxy)borohydride; acetic acid / water; acetonitrile / 3 h / 0 - 20 °C

With hydrogen bromide; sodium tris(acetoxy)borohydride; sodium hydride; acetic acid; In ethanol; water; N,N-dimethyl-formamide; toluene; acetonitrile;

Reference yield:

: 29313-32-4
2-phenylacetyl isothiocyanate

: 849217-36-3
1-{3-fluoro-4-[6-methoxy-7-(2-methyl-octahydro-cyclopenta[c]pyrrole-5-ylmethoxy)-quinazolin-4-yloxy]-phenyl}-3-phenylacetyl-thiourea

Guidance literature:: Multi-step reaction with 3 steps

1: ethanol; toluene / 1 - 2 h / 20 °C

2: hydrogen bromide; acetic acid / 1 h / 20 °C

3: sodium tris(acetoxy)borohydride; acetic acid / water; acetonitrile / 3 h / 0 - 20 °C

With hydrogen bromide; sodium tris(acetoxy)borohydride; acetic acid; In ethanol; water; toluene; acetonitrile;