4-((2-(2,6-dichlorobenzyl)-1H-benzo[d]imidazol-1-yl)methyl)-N,N-dimethylbenzamide

Base Information

Chemical Name:4-((2-(2,6-dichlorobenzyl)-1H-benzo[d]imidazol-1-yl)methyl)-N,N-dimethylbenzamide
CAS No.:1602748-02-6
Molecular Formula:C₂₄H₂₁Cl₂N₃O
Molecular Weight:438.356
Hs Code.:

Synonyms:4-((2-(2,6-dichlorobenzyl)-1H-benzo[d]imidazol-1-yl)methyl)-N,N-dimethylbenzamide

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 4-((2-(2,6-dichlorobenzyl)-1H-benzo[d]imidazol-1-yl)methyl)-N,N-dimethylbenzamide

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Technology Process of 4-((2-(2,6-dichlorobenzyl)-1H-benzo[d]imidazol-1-yl)methyl)-N,N-dimethylbenzamide

There total 6 articles about 4-((2-(2,6-dichlorobenzyl)-1H-benzo[d]imidazol-1-yl)methyl)-N,N-dimethylbenzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 42.0%

: 1602748-79-7
4-((2-(2,6-dichlorobenzyl)-1H-benzo[d]imidazole-1-yl)methyl)benzoic acid

: 124-40-3
dimethyl amine

: 1602748-02-6
4-((2-(2,6-dichlorobenzyl)-1H-benzo[d]imidazol-1-yl)methyl)-N,N-dimethylbenzamide

Guidance literature:: 4-((2-(2,6-dichlorobenzyl)-1H-benzo[d]imidazole-1-yl)methyl)benzoic acid; With oxalyl dichloride; In dichloromethane; N,N-dimethyl-formamide; at 20 ℃; for 2h; Inert atmosphere;

dimethyl amine; With N-ethyl-N,N-diisopropylamine; In dichloromethane; N,N-dimethyl-formamide; at 20 ℃; for 16h; Inert atmosphere;
DOI:10.1016/j.ejmech.2016.11.017

Reference yield: 28.0%

: 1602748-02-6
4-((2-(2,6-dichlorobenzyl)-1H-benzo[d]imidazol-1-yl)methyl)-N,N-dimethylbenzamide

Guidance literature:: With (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; N-ethyl-N,N-diisopropylamine; In N,N-dimethyl-formamide; at 20 ℃;

Reference yield:

: 95-54-5
1,2-diamino-benzene

: 1602748-02-6
4-((2-(2,6-dichlorobenzyl)-1H-benzo[d]imidazol-1-yl)methyl)-N,N-dimethylbenzamide

Guidance literature:: Multi-step reaction with 4 steps

1.1: polyphosphoric acid / 4 h / Inert atmosphere; Heating

2.1: sodium hydride / N,N-dimethyl-formamide / 16 h / 20 °C / Inert atmosphere

3.1: lithium hydroxide / tetrahydrofuran; water; methanol / 3 h / 20 °C

4.1: oxalyl dichloride / N,N-dimethyl-formamide; dichloromethane / 2 h / 20 °C / Inert atmosphere

4.2: 16 h / 20 °C / Inert atmosphere

With oxalyl dichloride; sodium hydride; lithium hydroxide; In tetrahydrofuran; methanol; dichloromethane; water; N,N-dimethyl-formamide;
DOI:10.1016/j.ejmech.2016.11.017