(5-{6-[2-(2-fluoro-4-trifluoromethyl-phenyl)-ethylamino]-2-methoxy-pyrimidin-4-yl}-1H-indol-3-yl)-acetic acid

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Chemical Name:(5-{6-[2-(2-fluoro-4-trifluoromethyl-phenyl)-ethylamino]-2-methoxy-pyrimidin-4-yl}-1H-indol-3-yl)-acetic acid
CAS No.:885068-03-1
Molecular Formula:C₂₄H₂₀F₄N₄O₃
Molecular Weight:488.441
Hs Code.:

Synonyms:(5-{6-[2-(2-fluoro-4-trifluoromethyl-phenyl)-ethylamino]-2-methoxy-pyrimidin-4-yl}-1H-indol-3-yl)-acetic acid

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Chemical Property of (5-{6-[2-(2-fluoro-4-trifluoromethyl-phenyl)-ethylamino]-2-methoxy-pyrimidin-4-yl}-1H-indol-3-yl)-acetic acid

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Technology Process of (5-{6-[2-(2-fluoro-4-trifluoromethyl-phenyl)-ethylamino]-2-methoxy-pyrimidin-4-yl}-1H-indol-3-yl)-acetic acid

There total 4 articles about (5-{6-[2-(2-fluoro-4-trifluoromethyl-phenyl)-ethylamino]-2-methoxy-pyrimidin-4-yl}-1H-indol-3-yl)-acetic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 17.0%

: 885068-06-4
3-carboxymethyl-1H-indol-5-yl-boronic acid

: 885068-04-2
(6-chloro-2-methoxy-pyrimidin-4-yl)-[2-(2-fluoro-4-trifluoromethyl-phenyl)-ethyl]-amine

: 885068-03-1
(5-{6-[2-(2-fluoro-4-trifluoromethyl-phenyl)-ethylamino]-2-methoxy-pyrimidin-4-yl}-1H-indol-3-yl)-acetic acid

Guidance literature:: 3-carboxymethyl-1H-indol-5-yl-boronic acid; (6-chloro-2-methoxy-pyrimidin-4-yl)-[2-(2-fluoro-4-trifluoromethyl-phenyl)-ethyl]-amine; With caesium carbonate; In ethanol; water; toluene; for 0.0833333h;

tetrakis(triphenylphosphine) palladium⁽⁰⁾; In ethanol; water; toluene; at 130 ℃; for 0.25h; Microwave;

Reference yield:

: 239087-11-7
[2-fluoro-4-(trifluoromethyl)phenyl]acetonitrile

: 885068-03-1
(5-{6-[2-(2-fluoro-4-trifluoromethyl-phenyl)-ethylamino]-2-methoxy-pyrimidin-4-yl}-1H-indol-3-yl)-acetic acid

Guidance literature:: Multi-step reaction with 3 steps

1: hydrogenchloride; hydrogen / palladium 10% on activated carbon / ethanol; water / 15 h / 20 °C

2: sodium hydrogencarbonate / ethanol / 5 h / Heating / reflux

3: caesium carbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / ethanol; water; toluene / 0.33 h / 130 °C / Microwave

With hydrogenchloride; hydrogen; sodium hydrogencarbonate; caesium carbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; palladium 10% on activated carbon; In ethanol; water; toluene;

Reference yield:

: 885068-05-3
2-(2-fluoro-4-trifluoromethyl-phenyl)-ethylamine hydrochloride

: 885068-03-1
(5-{6-[2-(2-fluoro-4-trifluoromethyl-phenyl)-ethylamino]-2-methoxy-pyrimidin-4-yl}-1H-indol-3-yl)-acetic acid

Guidance literature:: Multi-step reaction with 2 steps

1: sodium hydrogencarbonate / ethanol / 5 h / Heating / reflux

2: caesium carbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / ethanol; water; toluene / 0.33 h / 130 °C / Microwave

With sodium hydrogencarbonate; caesium carbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In ethanol; water; toluene;