3-{6-[2-(2-fluoro-4-trifluoromethyl-phenyl)-ethylamino]-2-methoxy-pyrimidin-4-yl}-phenol

Base Information

Chemical Name:3-{6-[2-(2-fluoro-4-trifluoromethyl-phenyl)-ethylamino]-2-methoxy-pyrimidin-4-yl}-phenol
CAS No.:885068-30-4
Molecular Formula:C₂₀H₁₇F₄N₃O₂
Molecular Weight:407.367
Hs Code.:

Synonyms:3-{6-[2-(2-fluoro-4-trifluoromethyl-phenyl)-ethylamino]-2-methoxy-pyrimidin-4-yl}-phenol

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Chemical Property of 3-{6-[2-(2-fluoro-4-trifluoromethyl-phenyl)-ethylamino]-2-methoxy-pyrimidin-4-yl}-phenol

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Technology Process of 3-{6-[2-(2-fluoro-4-trifluoromethyl-phenyl)-ethylamino]-2-methoxy-pyrimidin-4-yl}-phenol

There total 5 articles about 3-{6-[2-(2-fluoro-4-trifluoromethyl-phenyl)-ethylamino]-2-methoxy-pyrimidin-4-yl}-phenol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 885068-04-2
(6-chloro-2-methoxy-pyrimidin-4-yl)-[2-(2-fluoro-4-trifluoromethyl-phenyl)-ethyl]-amine

: 87199-18-6
3-hydroxyphenylboronic acid

: 885068-30-4
3-{6-[2-(2-fluoro-4-trifluoromethyl-phenyl)-ethylamino]-2-methoxy-pyrimidin-4-yl}-phenol

Guidance literature:: (6-chloro-2-methoxy-pyrimidin-4-yl)-[2-(2-fluoro-4-trifluoromethyl-phenyl)-ethyl]-amine; 3-hydroxyphenylboronic acid; With caesium carbonate; In 1,2-dimethoxyethane; water; for 0.0833333h;

tetrakis(triphenylphosphine) palladium⁽⁰⁾; In 1,2-dimethoxyethane; water; at 20 - 85 ℃; for 15h;

Reference yield:

: 885068-03-1
(5-{6-[2-(2-fluoro-4-trifluoromethyl-phenyl)-ethylamino]-2-methoxy-pyrimidin-4-yl}-1H-indol-3-yl)-acetic acid

: 87199-18-6
3-hydroxyphenylboronic acid

: 885068-30-4
3-{6-[2-(2-fluoro-4-trifluoromethyl-phenyl)-ethylamino]-2-methoxy-pyrimidin-4-yl}-phenol

Guidance literature:: With caesium carbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In 1,2-dimethoxyethane; water; at 20 - 85 ℃; for 15.0833h;

Reference yield:

: 239087-11-7
[2-fluoro-4-(trifluoromethyl)phenyl]acetonitrile

: 885068-30-4
3-{6-[2-(2-fluoro-4-trifluoromethyl-phenyl)-ethylamino]-2-methoxy-pyrimidin-4-yl}-phenol

Guidance literature:: Multi-step reaction with 4 steps

1: hydrogenchloride; hydrogen / palladium 10% on activated carbon / ethanol; water / 15 h / 20 °C

2: sodium hydrogencarbonate / ethanol / 5 h / Heating / reflux

3: caesium carbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / ethanol; water; toluene / 0.33 h / 130 °C / Microwave

4: caesium carbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 1,2-dimethoxyethane; water / 15.08 h / 20 - 85 °C

With hydrogenchloride; hydrogen; sodium hydrogencarbonate; caesium carbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; palladium 10% on activated carbon; In 1,2-dimethoxyethane; ethanol; water; toluene;