(R,E)-7-(3-(4-fluorophenyl)-1-isopropyl-1H-indol-2-yl)-5-hydroxy-3-oxohept-6-enoic acid isopropyl ester

Base Information

Chemical Name:(R,E)-7-(3-(4-fluorophenyl)-1-isopropyl-1H-indol-2-yl)-5-hydroxy-3-oxohept-6-enoic acid isopropyl ester
CAS No.:1254361-95-9
Molecular Formula:C₂₇H₃₀FNO₄
Molecular Weight:451.538
Hs Code.:

Synonyms:(R,E)-7-(3-(4-fluorophenyl)-1-isopropyl-1H-indol-2-yl)-5-hydroxy-3-oxohept-6-enoic acid isopropyl ester

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Chemical Property of (R,E)-7-(3-(4-fluorophenyl)-1-isopropyl-1H-indol-2-yl)-5-hydroxy-3-oxohept-6-enoic acid isopropyl ester

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Technology Process of (R,E)-7-(3-(4-fluorophenyl)-1-isopropyl-1H-indol-2-yl)-5-hydroxy-3-oxohept-6-enoic acid isopropyl ester

There total 1 articles about (R,E)-7-(3-(4-fluorophenyl)-1-isopropyl-1H-indol-2-yl)-5-hydroxy-3-oxohept-6-enoic acid isopropyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 84.0%

: 674-82-8,2130-41-8
4-methyleneoxetan-2-one

: 93957-50-7
3-<3-(4-fluorophenyl)-1-(1-methylethyl)-1H-indol-2-yl>-2(E)-propenal

: 67-63-0,8013-70-5
isopropyl alcohol

: 1254361-95-9
(R,E)-7-(3-(4-fluorophenyl)-1-isopropyl-1H-indol-2-yl)-5-hydroxy-3-oxohept-6-enoic acid isopropyl ester

Guidance literature:: 4-methyleneoxetan-2-one; 3-<3-(4-fluorophenyl)-1-(1-methylethyl)-1H-indol-2-yl>-2(E)-propenal; With titanium(IV) isopropylate; (R)-2-(N-3-tert-butylsalicylidene)amino-3-methyl-1-butanol; In dichloromethane; at -40 ℃; for 48h; Inert atmosphere;

isopropyl alcohol; In dichloromethane; at -40 ℃; for 3h; Inert atmosphere;

With hydrogenchloride; In diethyl ether; dichloromethane; water; at 20 ℃; for 1h; optical yield given as %ee; enantioselective reaction; Inert atmosphere;
DOI:10.1021/jo101542y

Reference yield: 79.0%

: 1254361-95-9
(R,E)-7-(3-(4-fluorophenyl)-1-isopropyl-1H-indol-2-yl)-5-hydroxy-3-oxohept-6-enoic acid isopropyl ester

: 1254361-99-3
(3S,5R,E)-7-(3-(4-fluorophenyl)-1-isopropyl-1H-indol-2-yl)-3,5-dihydroxyhept-6-enoic acid isopropyl ester

Guidance literature:: (R,E)-7-(3-(4-fluorophenyl)-1-isopropyl-1H-indol-2-yl)-5-hydroxy-3-oxohept-6-enoic acid isopropyl ester; With sodium tetrahydroborate; diethyl methoxy borane; In tetrahydrofuran; methanol; at -78 ℃; for 3h; Inert atmosphere;

With water; sodium hydrogencarbonate; In tetrahydrofuran; methanol; n-heptane; ethyl acetate; optical yield given as %de; diastereoselective reaction; Inert atmosphere;
DOI:10.1021/jo101542y

Reference yield: 44.0%

: 1254361-95-9
(R,E)-7-(3-(4-fluorophenyl)-1-isopropyl-1H-indol-2-yl)-5-hydroxy-3-oxohept-6-enoic acid isopropyl ester

: 1254361-99-3
(3S,5R,E)-7-(3-(4-fluorophenyl)-1-isopropyl-1H-indol-2-yl)-3,5-dihydroxyhept-6-enoic acid isopropyl ester

: 1254362-03-2
(3R,5R,E)-7-(3-(4-fluorophenyl)-1-isopropyl-1H-indol-2-yl)-3,5-dihydroxyhept-6-enoic acid isopropyl ester

Guidance literature:: With acetic acid; tetramethylammonium triacetoxyborohydride; In acetonitrile; at -40 ℃; for 16h; optical yield given as %de;
DOI:10.1021/jo101542y