N-(2-{4-[4-chloro-6-(6,7,9,10,12,13,15,16,18,19-decahydro-5,8,11,14,17,20-hexaoxa-benzocyclooctadecen-2-ylamino)-[1,3,5]triazin-2-ylamino]-phenyl}-ethyl)-2,2,2-trifluoro-acetamide

Base Information Edit

Chemical Name:N-(2-{4-[4-chloro-6-(6,7,9,10,12,13,15,16,18,19-decahydro-5,8,11,14,17,20-hexaoxa-benzocyclooctadecen-2-ylamino)-[1,3,5]triazin-2-ylamino]-phenyl}-ethyl)-2,2,2-trifluoro-acetamide
CAS No.:411223-78-4
Molecular Formula:C₂₉H₃₄ClF₃N₆O₇
Molecular Weight:671.073
Hs Code.:
Mol file:411223-78-4.mol

<i>N</i>-(2-{4-[4-chloro-6-(6,7,9,10,12,13,15,16,18,19-decahydro-5,8,11,14,17,20-hexaoxa-benzocyclooctadecen-2-ylamino)-[1,3,5]triazin-2-ylamino]-phenyl}-ethyl)-2,2,2-trifluoro-acetamide

Synonyms:N-(2-{4-[4-chloro-6-(6,7,9,10,12,13,15,16,18,19-decahydro-5,8,11,14,17,20-hexaoxa-benzocyclooctadecen-2-ylamino)-[1,3,5]triazin-2-ylamino]-phenyl}-ethyl)-2,2,2-trifluoro-acetamide

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Chemical Property of N-(2-{4-[4-chloro-6-(6,7,9,10,12,13,15,16,18,19-decahydro-5,8,11,14,17,20-hexaoxa-benzocyclooctadecen-2-ylamino)-[1,3,5]triazin-2-ylamino]-phenyl}-ethyl)-2,2,2-trifluoro-acetamide Edit

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Technology Process of N-(2-{4-[4-chloro-6-(6,7,9,10,12,13,15,16,18,19-decahydro-5,8,11,14,17,20-hexaoxa-benzocyclooctadecen-2-ylamino)-[1,3,5]triazin-2-ylamino]-phenyl}-ethyl)-2,2,2-trifluoro-acetamide

There total 1 articles about N-(2-{4-[4-chloro-6-(6,7,9,10,12,13,15,16,18,19-decahydro-5,8,11,14,17,20-hexaoxa-benzocyclooctadecen-2-ylamino)-[1,3,5]triazin-2-ylamino]-phenyl}-ethyl)-2,2,2-trifluoro-acetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 53.0%

: 108-77-0
1,3,5-trichloro-2,4,6-triazine

: 24954-62-9
N-[2-(4-aminophenyl)ethyl]-2,2,2-trifluoroacetamide

: 68941-06-0
4-aminobenzo-18-crown-6

: 411223-78-4
N-(2-{4-[4-chloro-6-(6,7,9,10,12,13,15,16,18,19-decahydro-5,8,11,14,17,20-hexaoxa-benzocyclooctadecen-2-ylamino)-[1,3,5]triazin-2-ylamino]-phenyl}-ethyl)-2,2,2-trifluoro-acetamide

Guidance literature:: 1,3,5-trichloro-2,4,6-triazine; N-[2-(4-aminophenyl)ethyl]-2,2,2-trifluoroacetamide; With triethylamine; In tetrahydrofuran; at 20 ℃; for 4h;

4-aminobenzo-18-crown-6; With triethylamine; In tetrahydrofuran; at 45 ℃; for 12h; Further stages.;
DOI:10.1021/ol0170915

Reference yield:

: 411223-78-4
N-(2-{4-[4-chloro-6-(6,7,9,10,12,13,15,16,18,19-decahydro-5,8,11,14,17,20-hexaoxa-benzocyclooctadecen-2-ylamino)-[1,3,5]triazin-2-ylamino]-phenyl}-ethyl)-2,2,2-trifluoro-acetamide

: 411223-79-5
N-[4-(2-amino-ethyl)-phenyl]-N',N'-dibutyl-N''-(6,7,9,10,12,13,15,16,18,19-decahydro-5,8,11,14,17,20-hexaoxa-benzocyclooctadecen-2-yl)-[1,3,5]triazine-2,4,6-triamine

Guidance literature:: Multi-step reaction with 2 steps

1: tetrahydrofuran / 12 h / Heating

2: NH₃ / methanol / 20 °C

With ammonia; In tetrahydrofuran; methanol;
DOI:10.1021/ol0170915