N-methoxy-N-methyl-2-(4-(trifluoromethyl)phenyl)cyclopropane-1-carboxamide

Base Information

Chemical Name:N-methoxy-N-methyl-2-(4-(trifluoromethyl)phenyl)cyclopropane-1-carboxamide
CAS No.:956283-15-1
Molecular Formula:C₁₃H₁₄F₃NO₂
Molecular Weight:273.255
Hs Code.:

Synonyms:N-methoxy-N-methyl-2-(4-(trifluoromethyl)phenyl)cyclopropane-1-carboxamide

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Chemical Property of N-methoxy-N-methyl-2-(4-(trifluoromethyl)phenyl)cyclopropane-1-carboxamide

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Technology Process of N-methoxy-N-methyl-2-(4-(trifluoromethyl)phenyl)cyclopropane-1-carboxamide

There total 5 articles about N-methoxy-N-methyl-2-(4-(trifluoromethyl)phenyl)cyclopropane-1-carboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

: 1355061-77-6
N-methoxy-N-methyl-3-(4-trifluoromethyl-phenyl)-acrylamide

: 1774-47-6
trimethylsulfoxonium iodide

: 956283-15-1
N-methoxy-N-methyl-2-(4-(trifluoromethyl)phenyl)cyclopropane-1-carboxamide

Guidance literature:: With sodium hydride; In dimethyl sulfoxide; at 20 ℃; for 18h;

Reference yield: 76.0%

: 1774-47-6
trimethylsulfoxonium iodide

: 201164-14-9
(E)-N-methoxy-N-methyl-3-(4-(trifluoromethyl)phenyl)acrylamide

: 956283-15-1
N-methoxy-N-methyl-2-(4-(trifluoromethyl)phenyl)cyclopropane-1-carboxamide

Guidance literature:: trimethylsulfoxonium iodide; With sodium hydride; In dimethyl sulfoxide; at 20 ℃;

(E)-N-methoxy-N-methyl-3-(4-(trifluoromethyl)phenyl)acrylamide; In dimethyl sulfoxide; at 20 ℃;
DOI:10.1021/acs.jmedchem.9b01835

Reference yield:

: 455-19-6
4-Trifluoromethylbenzaldehyde

: 956283-15-1
N-methoxy-N-methyl-2-(4-(trifluoromethyl)phenyl)cyclopropane-1-carboxamide

Guidance literature:: Multi-step reaction with 4 steps

1.1: dichloromethane / 20 °C

2.1: lithium hydroxide monohydrate / tetrahydrofuran; water / 2 h / 20 °C

3.1: N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate; sodium hydrogencarbonate / N,N-dimethyl-formamide / 20 °C

4.1: sodium hydride / dimethyl sulfoxide / 20 °C

4.2: 20 °C

With lithium hydroxide monohydrate; sodium hydride; sodium hydrogencarbonate; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate; In tetrahydrofuran; dichloromethane; water; dimethyl sulfoxide; N,N-dimethyl-formamide; 1.1: |Wittig Olefination;
DOI:10.1021/acs.jmedchem.9b01835