4-(dimethylamino)-3-methylbenzoic acid

Base Information

• Chemical Name: 4-(dimethylamino)-3-methylbenzoic acid
• CAS No.: 103030-89-3
• Molecular Formula: C₁₀H₁₃NO₂
• Molecular Weight: 179.219
• Mol file: 103030-89-3.mol

Synonyms:4-(N,N-dimethylamino)-3-methylbenzoic acid

Chemical Property of 4-(dimethylamino)-3-methylbenzoic acid

Chemical Property:

• Melting Point: 131-132 °C(Solv: ethanol, 50% (64-17-5))
• Boiling Point: 316.6±30.0 °C(Predicted)
• PKA: 4.98±0.10(Predicted)
• Density: 1.147±0.06 g/cm3(Predicted)

Purity/Quality:

95+% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 4-(dimethylamino)-3-methylbenzoic acid

There total 3 articles about 4-(dimethylamino)-3-methylbenzoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 56.0%

3-methyl-4-(dimethylamino)-benzaldehyde (1424-69-7) → 4-(N,N-dimethylamino)-3-methylbenzoic acid (103030-89-3)

Guidance literature:

With potassium hydroxide; sodium hydroxide; In neat (no solvent); Heating;

DOI:10.1080/00304948.2017.1260396

Reference yield:

2-methyl-4-bromo-N,N-dimethylaniline (50638-49-8) → 4-(N,N-dimethylamino)-3-methylbenzoic acid (103030-89-3)

Guidance literature:

With diethyl ether; lithium; anschliessend Behandeln mit CO₂;

DOI:10.1021/ja01156a114

Reference yield:

formaldehyd (50-00-0,30525-89-4,61233-19-0) + 3-methyl-4-nitrobenzoic acid (3113-71-1) → 4-(N,N-dimethylamino)-3-methylbenzoic acid (103030-89-3)

Guidance literature:

With methanol; palladium on activated charcoal; under 22065.2 - 29420.3 Torr; Hydrogenation;

upstream raw materials:

formaldehyd

3-methyl-4-nitrobenzoic acid

2-methyl-4-bromo-N,N-dimethylaniline

3-methyl-4-(dimethylamino)-benzaldehyde

Downstream raw materials:

4-dimethylamino-3-methyl-benzoic acid ethyl ester

Refernces